The action of some isoquinoline derivatives / by P.P. Laidlaw.

  • Laidlaw, Patrick P. (Patrick Playfair), Sir, 1881-1940.
Date:
[1911?]
Catalogue details

Licence: Public Domain Mark

Credit: The action of some isoquinoline derivatives / by P.P. Laidlaw. Source: Wellcome Collection.

    12/36 page 252
    Reduce this to 6 :7-dimethoxy 2-methyl-tetrahydro-iso-quinoline and the strychnine-like effect reappears in full strength. CH30 ch3 0 It is thus evident that a different law prevails in the case of iso-quinoline derivatives without a methyl group on the nitrogen, but sufficient examples are not available for a generalisation. It seems clear, however, if the compounds containing hydroxy groups or keto groups are excepted, that one generalisation will cover all these iso-quinoline alkaloids. Iso-quinoline compounds substituted in G : 7 :8 positions with methoxy or methylene-dioxy groups are convulsant when the nitrogen is trivalent, and are devoid of this effect when the nitrogen is pentavalent. Part II The alkaloid which forms the subject of this part of the paper is 6 : 7-dimethoxy 2-methyl 3 :4-dihydro-iso-quinolinium chloride. As will be seen from the structural formulae below, it has close chemical relationships with hydrastinine and cotarnine. These two alkaloids have for long enjoyed a reputation in therapeutics as haemostatics, particularly in abnormal uterine conditions. The similarity in chemical constitution suggests a similarity in physiological action. This would seem to be the more probable when the similar action of the parent alkaloids and other derivatives from them is taken into account. Reference to the earlier part of this paper will make this point clearer. The close relationship between the new alkaloid and hydrastinine and cotarnine is well shown in their structural formulae. OH., V'N/ CH CH, N • CH, Cl diamethoxy 2 methyl dihydro iso-quinolinium chloride. CH2 N • CH3 Cl CH Hydrastinine chloride. Cotarnine chloride.
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