The experimental production of Anæmia in dogs / by Ralph Stockman.

  • Stockman, Ralph.
Date:
[1896]
Catalogue details

Licence: Public Domain Mark

Credit: The experimental production of Anæmia in dogs / by Ralph Stockman. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

    4/8 page 386
    Date. Per cent, Hb. Red Corpuscles. uu. Value of each Corpuscle. Bled to Remarks. Hrtf OA 8,000,000 1 '0 OV C. C. >) ^^ 108 OO ,, 9Q >> 94 6 080 000 I'O 92 Onmn ^f»l pti wpI 1 lUlXIlcU. Q1 ,, 6\ cs^ p: 7y1A AAA JN OV, 1 / 0 a QAA Ann 0 QO U ^Z Lyorpuscics well many microcytes; sp. gi\ of serum, 1-012. o OO 6,280,000 O'RO 7 60 r A (\r\ f\C\r\ 0,400,000 n -Qo U oZ 1^0 ,, op, gr, ot blood.) 1 v^l J yjl ODrUlU, 1 099 12 50 5,640,000 0-65 120 „ Sp. gr. of blood, T ■ of Rftrnm JL \/tJKJ f \Jk OOA mil, Do/ CL* 1 •094. 16 A O K oQA Ann U DO „ 21 48 r cnn nnn n -PS) .■^lirrlrf nAilril APTrtAQiQ Oz 090 000 0*64 Corpuscles very Uec. 0 oz ft ooo 000 0*61 pale, many some- ,, 13 oz 1 ,900 000 Avhat missliapen, „ 20 54 8,700,000 0-46 and a few nu- ,, 28 62 9,200,000 0-60 cleated. .Jan. 3 72 10,000,000 0-52 „ 17 90 11,200,000 0-60 ,, 30 98 10,400,000 0-69 Feb. 20 104 10,320,000 0-74 On looking over the experiment, it will be observed that the red corpuscles and haemoglobin diminished at first in equal proportions, but in a very short time the deficiency in haemoglobin became much the more marked, and after the last bleeding, when both were at their lowest ebb, the hemoglobin had sunk to less than half its original amount, while the corpuscles had fallen only about one-third. In one month the corpuscles had returned to their original number, the hsemo- CTlobin having by this time gained only 4 per cent., and three months elapsed before the latter had returned even approximately to its original amount. There was some poikilocytosis with a good many microcytes, and the blood serimi was .little altered in specific gravity, although the specific gravity of the blood fell considerably, thus indicating that the deficiency was in the corpuscles. The hsmoo-lobin value of the individual corpuscle also became very low. All this is similar to the blood condition found in chlorosis, and if the experiment had been stopped sooner than it was, the impres- sion would have been produced that a condition exactly sunHar to chlorosis had been induced in the dog. But the animal went on producing more red corpuscles, until at one point the nudber reached over 11 millions per cub. mm., a state of affairs never seen m chlorosis, where the corpuscles are frequently normal m number, but
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