Proceedings of the Pathological Society of Great Britain and Ireland.

  • Bashford, Ernest Francis, 1873-
Date:
1908
Catalogue details

Licence: In copyright

Credit: Proceedings of the Pathological Society of Great Britain and Ireland. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    5/8 page 437
    THE CLINICAL BEHAVIOUR OF SPONTANEOUS TUMOURS IN MICE. By J. A. Murray. The spontaneous new growths of the mammary region of the mouse pursue the ordinary course of malignant growths met with in other animals and in man. The apparent encapsulation is very incomplete as seen by histological examination, and the results of extirpation confirm this. Local recurrence occurs in more than half the cases in which total surgical removal has been attempted. The interval which elapses between the operation and the recurrence varies from two or three weeks to several months. More remarkable are cases in which, without local recurrence, metastases are found in the lungs after a long interval. There is no clear evidence that operative interference increases the malignancy of the tumours. It is probable that some of the cases described as multiple tumours are in reality metastases. A TRANSPLANTABLE SQUAMOUS-CELLED CARCINOMA. By J. A. Murray and M. Haaland. The growth in question occurred in the left axillary region of an old female mouse. The primary growth was strongly keratinised in its central parts, while the periphery or more newly formed portions were mainly alveolar. A metastasis found in the lungs of the primary animal after death showed large areas of perfect keratinisation in the centre of the nodule; the periphery was alveolar as in the primary growth. The transplanted tumours, obtained after great initial difficulties, were at first purely alveolar carcinoma. Keratinisation again appeared in the eighth generation, so that large areas of the tumours consisted of horny masses. This condition persisted for two more generations, and then disappeared for several generations extending over a period of nearly three months. It has again appeared in some of the later tumours. The conditions governing the differentiation are not yet understood; an inherent periodicity in the life of the parenchyma cells seems to be the most satisfactory assumption to account for the facts at present. DEVELOPMENT OF A SPINDLE-CELLED SARCOMA DURING PROPAGATION OF AN ADENO-CARCINOMA OF A MOUSE. By M. Haaland. M hen a small piece of a carcinoma of the mouse is implanted into normal animals the parenchyma continues to grow (Jensen), the blood vessels and stroma degenerate, and are supplied afresh by the new host reacting to the chemiotactic influence proceeding from the parenchyma cells (Bashford, Murray, and Cramer). The connective tissue reactions thus elicited is specific for each form of malignant new growth, and without it a “graft” does not grow into a tumour. The parenchyma elements alone possess the power of continued growth in normal cases of successful transplantation, the degeneration of the transplanted stroma being invariable. Attempts to induce cancer experimentally by applying chemical, physical, or bacterial irritants, or to obtain tumour growth by transplanting normal embryonic and adult tissues, have, without exception, failed. In the course of the continued propagation of two alveolar carcinomata, Ehrlich and Apolant
    digitised image 1
    digitised image 2
    digitised image 3