New official remedies : containing all the drugs and preparations contained in the addendum (1890) to the British pharmacopoeia of 1885 : with pharmacological and therapeutical notes, adapted for the use of students and practitioners / by Ralph Stockman.

Date:
1891
Catalogue details

Licence: Public Domain Mark

Credit: New official remedies : containing all the drugs and preparations contained in the addendum (1890) to the British pharmacopoeia of 1885 : with pharmacological and therapeutical notes, adapted for the use of students and practitioners / by Ralph Stockman. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    of wafer paper, and consist of two watchglass-shaped halves, which cohere on moistening the edges). PhartnacologiccU Action.—Observations on man ami animals have shown that acetanilide acts as a powerful depressant of the nervous system. In large doses it markedly diminishes the spinal reflexes, and interferes with sensory and motor conduction in the cord. There is always a certain amount of analgesia produced, and, with very large doses, there may be complete sensory and motor paralysis. Tremors, sometimes deei)ening into convulsive movements, a marked fall in the temperature, coma, retention of urine and general paralysis, are seen with very large doses. The automatic functions of the medulla oblongata are markedly depressed. Consciousness is maintained until very late in the poisoning, and the cerebral functions are but little affected at a period when tlie spinal cord is deeply involved. Acetanilide has also a marked effect on the blood; in one or two hours, after administration of a large dose, the blootl becomes of a chocolate coloui from formation of methsmo- globin; it also contains less oxygen, its oxidising powers are much diminished, and there is a decrease in its alkalinity. Under the microscope the rod corpuscles are seen to be more globular and somewhat granular, and do not form rouleau.K. Their number is diminished, and the haemoglobin falls about 10 to 18 per cent, below tlie normal Blood- colouring matter may be found dissolved in the senim, especially if large doses have been given for some time. Small or moderate doses do not appreciably affect the blood. In conse«]uence of these actions on the blood and nervous system, poisonous doses tend to cause cyanosis, great dyspncea, and collapse. These are, however, essentially