On the physiological action of ulexin / by J. Rose Bradford.
- Bradford, John Rose, Sir, 1863-1935.
- Date:
- [1887?]
Licence: Public Domain Mark
Credit: On the physiological action of ulexin / by J. Rose Bradford. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![[From the Journal of Physiology. Vol. VIII. No. 2.] ON THE PHYSIOLOGICAL ACTION OF ULEXIN. By J. ROSE BRADFORD, B.Sc, M.R.C.S. (From the Physiological Laboratory of University College, London.) Ulexin is an alkaloid that has recently been prepared by Mr Gerrard1 (Pharmacist to University College Hospital) from the seeds of the com- mon gorse, Ulex Europaeus, and I have to thank him for the material used in this investigation. The hydrobromate was the salt used since this salt crystallizes more readily than any other, and so the drug is obtained in a greater degree of purity. My best thanks are due to Dr Ringer, F.R.S., (at whose suggestion the work was beguu), not only for the very kind manner in which he has assisted me with his advice, but also for the many occasions on which he was present at the experi- ments, and for the assistance I derived from his valuable criticism. Ulexin is an alkaloid that has a very general action on the tissues, besides a highly specialized action on the respiration, and so experiments were first made on frogs, mainly with regard to its action on muscle and nerve; and subsequently on the cat and dog. A few observations were also made on the eel with regard to the action of the drug on the heart, since in this animal the phenomena of inhibition2 are so much more readily investigated than in the frog. Since the work was begun, a paper by a French observer3 has appeared, detailing a few experiments on the frog only. Although the results obtained by myself agree in the main with his, yet there are some slight differences, and hence it may be more convenient if my own observations are given first, and the points of difference mentioned later. 1 A. W. Gerrard. Pharmaceutical Journal. Aug. 7, 188(i.. - J. A. McWilliam. Journal of Physiology. Yol. vi. Page 192. 3 Pinet. Archives <Ie Physiologic. Feb. 1887. Page 89.](https://iiif.wellcomecollection.org/image/b22398934_0005.jp2/full/800%2C/0/default.jpg)
