Progeria and ateleiosis / by Arthur Keith.

  • Arthur Keith
Date:
1913
Catalogue details

Licence: In copyright

Credit: Progeria and ateleiosis / by Arthur Keith. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    influence growth, although we may not yet know the manner nor the extent of their action. The association between acromegaly and adenoma of the pituitary can only be explained at present by supposing that the adenomatous pituitary, by means of a secretion which circulates in the tissues, has produced the series of growth changes seen in acromegaly.6 That is the only working hypothesis we have at present to explain the pathological changes in the pituitary and the growth changes in the tissues of the body. We have seen that those parts of the skeleton which are overgrown in acromegaly are undergrown in progeria. Fig. 11. ANT: border Transverse section at mid-point of the tibia from the case of progeria (shaded). Corresponding sections of the tibia from a boy of 18 and from a case of acromegaly are super- imposed (natural size). Acromegaly is not a general overgrowth of all the tissues and systems of the body ; its cause is selective in action. Progeria is not a generalised dwarfism ; the cause is also selective in its action, and affects those tissues and parts which are also affected in acromegaly. Figs. 5, 9, and 11 illustrate the truth of the statement; it is further exemplified in Fig. 12. In that figure the exact profiles of four mandibles are superimposed and accurately drawn to 6 For an account of skeletal changes in acromegaly see Keith, The Lancet, April 15th, 1911.
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