Volume 1
Pharmacographia indica : a history of the principal drugs of vegetable origin, met with in British India / by William Dymock ... C. J. H. Warden ... and David Hooper.
- William Dymock
- Date:
- 1890-93
Licence: Public Domain Mark
Credit: Pharmacographia indica : a history of the principal drugs of vegetable origin, met with in British India / by William Dymock ... C. J. H. Warden ... and David Hooper. Source: Wellcome Collection.
Provider: This material has been provided by King’s College London. The original may be consulted at King’s College London.
39/638
![actives, traduit par Morel, p. 13. The following extracts are made from the last-named work :— The tubers known as Bish, which have for some time been met with in commerce, contain an alkaloid, which, in its chemical reactions, presents a close analogy with acouitine. I find that the alkaloid of Bish, which has been called nepaline and pseudo-aconitine, can be quantitatively determined by the same process as aconitine, and that it gives the same reactions as that alkaloid. I may mention as a distinguishing character of this alkaloid, its greater^ solubility in boiling water and its being less soluble in ether and chloroform. I may, perhaps, also meutiou that utjlike the aconitine of Duquesnel, nepaline prepared by the same process is not precipitated by chloride of platinum. Nepaline can be estimated by means of Mayer's solution, one c.c. corresponding to 0*0388 grammes of the alka- loid ; I have obtained from farinaceous Bish extracted by water 1*81 and ] '82 per cent, and extracted by alcohol 1*15 and 1-04 per cent, of nepaline. If the action of the alcohol is prolonged for several days, a better result is obtained. One litre of Mayer's solutions contains 13*54-6 grm. of per- chloride of mercury and 49*8 .of iodide of potassium. Its action'is based upon the formation of a double iodide of the alkaloid very sparingly soluble in water, and composed of 1 eq. of iodide of aconitine and 1 eq. of biniodide of mercury. According to Wright and Luff, the formula for aconitia is C33 Hv3NO'Vand for pseudo-acouitine C36 H*9 NO12. F. Mandelin (Archiv. derPharm., February and March, 1885,) ■ gives the following as the conclusions he arrives at after a thorough investigation of the subject of aconitine:— 1. Japaconitine is identical with aconitine, and both are identical with a crystalline benzoylaconine. 2. Benzoylaconine is the only active principle of Aconilum Napellus, the other alkaloids contained in the plant being amorphous and pharmacologically unimportant. 3. The active principle of the roots of Aconiium ferox is however pseudo-aconitine or veratroylaconine.](https://iiif.wellcomecollection.org/image/b2129737x_0001_0039.jp2/full/800%2C/0/default.jpg)
