Volume 1

History and pathology of vaccination / by Edgar M. Crookshank.

  • Crookshank, Edgar M. (Edgar March), 1858-1928.
Date:
1889
Catalogue details

Licence: Public Domain Mark

Credit: History and pathology of vaccination / by Edgar M. Crookshank. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    XVIU and the ordinary results of a direct inoculation of Small-pox. In this case the appearances are strikingly dissimilar, but Adams selected a mild variety of Small-pox, called the pearl sort, and succeeded by cultivation on the human subject in producing appearances indistinguishable from ordinary vaccination.—E.M.C.] Plate VIII. VARIOLATION OF THE COW. {CEELY) facing p. Showing the progress of the variolation experiment on the fifteenth day. The variolous vesicle at its maximum of development with a large central crust; it had a florid glistening appearance. The vaccine vesicles of the seventh day were also at their greatest development, had slight central crust, and were surrounded, like the variolous vesicle, with a small pale areola.—(Ceely.) The whole history of this experiment is as follows :— Expcritticnt first.—Red and white sturk, thin skin, gentle, well bred :- Made seven punctures, and introduced fourteen points, charged half their length, near the left side of the vulva and below it. Inserted two setons, charged with Small-pox virus from the same subject, at the same time. Fiftli Day.—Two or three of the punctures tumid, all closed with brown plugs ; setons tumid. Si'.vf/i Day.—Some punctures tumid. Sevr/if/: Day.— Less tumid. Eightli Day.—Still less so ; setons passive, dry, adherent. Ninth Day.—No material alteration, and therefore vaccinated on the rigid side of the vulva, in seven punctures, with fifth, sixth, and seventh daj' lymph, on fourteen points, from a young child ; and hcloiv the vulva, in four punctures, with eight points. Tenili day of variolation, second of vaccination : Some of the variolated punctures hard and elevated ; but one, near the margin of the vulva, has assumed the form and appearance of the vaccine vesicle ; it is nearly circular, has an elevated margin, and a small crust in the depressed centre. By gently removing the central irregular crust, and careful|ly puncturing the cuticle from under which this appears to have exuded, lymph was obtained, and thirty-eight points were scantily charged in the course of an hour. Vaccinated punctures on the right side, rather red and elevated. Eleventli day of variolation, tliird day of vaccination: The circular indurated intumescence, forming the margin of the vesicle, somewhat flattened and diminished. Vaccine punctures more red, larger, and more elevated. Evening: more crust in the centre of the Small-pox vesicle; margin less elevated. Vaccine vesicles advancing. Twelfth day of variolation, fotirtli day of vaccination : Margin of the Small-pox vesicle more elevated and red ; central crust darker ; two of the other variolous punctures more tumid, but without Ij'mph, still merely tubercular. Vaccinated punctures more tumid and inflamed. Tliirteentli day of variolation, fifth day of vaccination : Small-pox vesicle more inflam.ed, nearly as florid as the mucous membrane of the vulva, which has lately assumed a bright rose colour. Every puncture made for the vaccine lymph (five days since) effectual, vesicles of different forms and sizes being now apparent. Charged some points from them. Fourteentli day of variolation, sixth of vaccination: Small-pox vesicle