Collected papers / edited by W. D. Halliburton.
- King's College, London. Physiological Laboratory.
- Date:
- 1897
Licence: Public Domain Mark
Credit: Collected papers / edited by W. D. Halliburton. Source: Wellcome Collection.
Provider: This material has been provided by King’s College London. The original may be consulted at King’s College London.
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![[From the Journal of Physiology. Vol. XVIII. No. 4, 1895.] THE INTRAVASCULAR COAGULATION PRODUCED BY SYNTHESISED COLLOIDS. By W. D. HALLI- BURTON, M.D., F.R.S., AND J. W. PICKERING, D. Sc., George Henry Lewes Student. {From the Physiological Laboratory of King’s College, London.) Introduction. Recent investigations have shown that there are two classes of substances, both metabolic products of the organism, which when intravenously injected will introduce intravascular clotting. The first class, termed nucleo-albumins h consists of various tissue extracts all of which are characterised by containing nuclein, and consequently phosphorus; while the second class, which includes the proteoses of the venom of certain snakes '', is distinguished by the absence of phos- phorus from its molecule. More recently one of us (Pickering^) has published an account of the effect produced by the intravenous injection of certain synthesised colloids, which in their characteristic reactions are strikingly similar to proteids. The following is a summary of the chief points contained in that paper: (1) Three synthesised colloids, hereinafter termed the colloids A, B, and C, respectively were investigated. The colloids A and B are formed by the interaction of phosphorous pentachloride and meta-amidobenzoic acid in sealed tubes at a temperature of 125° and 135° C. respectively. The resulting products are according to their discoverer. Prof. Grimaux'* of Paris, intramolecular anhydrides formed by the union of several molecules of meta-amidobenzoic acid with the ^ Halliburton and Brodie. This J’owraai!, xvii. 135. Pekelharing, Gentralblatt fiir Physioloyie. 4 Mai, 1895. Hft. 3. * Martin and McGarvie-Smith. Proc. Roy. Soc. N.S.W. (1892), and this Journal, XV. 380 (1894). 2 Pickering. This Journal, xviii. 54 (1895). Comptes Rendus de VAcaddmic des Sciences (Paris), 17 Juin, 1895, T. cxx. p. 1348, and Comptes Rendus de la Sociitd de Biologie, 14 Juin, 1895. ■* Full bibliographical notice of Grimaux’s researches will be found in Pickering’s paper in this Journal. PH. XVIII.](https://iiif.wellcomecollection.org/image/b21303733_0025.jp2/full/800%2C/0/default.jpg)
