Arsinic acids derived from guaiacol and veratrole. Constitution of the polyarsenides / by Robert George Fargher.

  • Fargher, Robert George.
Date:
1920.]
Catalogue details

Licence: Public Domain Mark

Credit: Arsinic acids derived from guaiacol and veratrole. Constitution of the polyarsenides / by Robert George Fargher. Source: Wellcome Collection.

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    XCVIL—Arsinic Acids Derived from Guaiacol and. Veratrole. Constitution of the Poly arsenides. By Robert George Fargher. The literature of the organic compounds of arsenic contains no account of the arsinic acids derived from guaiacol and veratrole though the conversion of ^hydroxyphenylarsinic acid into a dihydroxy-acid, presumably 3 :4-dihydroxyphenylarsinic acid, by means of potassium persulphate has been claimed (D.R.-P. 271892). Trial of this reaction showed that the yield was poor and the product a mixture of 3:4-dihydroxyphenylarsinic acid with the unchanged acid. These were separable with difficulty, and their identity was most readily established by complete methylation and fractional crystallisation of the product. 3-Amino-4-hydroxyphenylarsinic acid and 3-aminoA-methoxy- phenylarsinic acid presented an alternative source, but the energetic treatment required to effect the decomposition of their diazo-compounds (compare D.R.-P. 95339; J. Soc. Chem. Ind., 1898, 17, 314; P., 1905, 21. 206; French Pats., 167211, 228539) resulted in the almost entire destruction of the arsenical com¬ plex. The Bucherer reaction (compare Ber1917, 50, 101, where earlier references are given) also proved to be inapplicable. The reaction devised by Bart (D.R.-P. 250264, 254092, 254345) therefore presented the most satisfactory method of obtaining the required substances. The preparation of the necessary amines was facilitated by the appearance of a communication by Cardwed and
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