The specificity of serological reactions / by Karl Landsteiner.

  • Landsteiner, Karl, 1868-1943.
Date:
[1936], ©1936
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Licence: Public Domain Mark

Credit: The specificity of serological reactions / by Karl Landsteiner. Source: Wellcome Collection.

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    ity, depends on the physico-chemical properties of the sub- strate, e.g., the greater or lesser stability of bacterial suspen- sions, and subsidiary conditions. From recent evidence it appears that the specific forces may intervene also in the agglutination during the second stage. As Topley and his col- leagues (24) showed, when a mixture of twro sorts of bacteria was acted upon by a mixture of the two specific agglutinins, the clumps each con- sisted of one bacterial variety only, rather than being indifferently made up of both [cf. Abramson (25)]. I his result supports the theory advanced by Marrack and by Heidelberger that due to the specific forces during the second stage of agglutination and precipitation a lattice is formed consist- ing, in the words of I opley, of masses of antigen and antibody molecules bound together by specific linkages, any one antigen molecule within the mass being united to two or more molecules of antibody, any one molecule of antibody to two or more molecules of antigen . . . . ” BIBLIOGRAPHY References with the designation B should be consulted for papers not listed. (1) Sachs: Handb. d. path. Mikr. 2 (1929) 834.—(2) Willstätter: Unter- suchungen über Enzyme. Berlin, Springer, 1928; Z. physiol. Chem. 151 G925) 273—(3) Waldschmidt-Leitz: Vorträge aus dem Gebiete der Eiweiss- chemie. Leipzig, 1931, p. 69.—(4) Quastei: Biochem. J. 25 (1931) 1121; Proc. Roy. Soc. B in (1932) 294.—(4a) Pepeu: Atti V Congr. Naz. Microb., Milano 1935, p. 161— (5) Robert: Lehrbuch der Intoxikationen, Stuttgart, Enke, 1906.—(6) Schiff: Oppenheimers Handb. Biochem. 3 (1924) 346.—(7) Landsteiner and Raubitschek: Zbl. Bakter. 45 (1907) 660.—(8) v. Eisler: Z. Immun, forsch. 1 (1908) 151, Zbl. Bakter. 66 (I912) 309.—(9) Mendel: Arch, di Fisiol. 7 (1909) 168.—(10) Robert: Beitr. z. Kenntn. der vegetabilischen Hämagglutinine, Landwirtsch. Ver- suchsstal. 79 (1913) 82, Berlin, Parey.—(11) Ryes and Sachs: Bcrl. klin. Wsehr. 1903, p. 21.—(12) Ryes: Z. physiol. Chem. 41 (1004) 273.—(13) Sachs: Beitr. z. Chem., Phys. u. Path. 2 (1902) 125.—(14) Thompson: Z. physiol. Chem. 29 (1900) n.—(15) Landsteiner: Münch, med. Wschr. 1904, p. 1185: v. Z. Immun, forsch. 14 (1912) 21.—(16) Browming: Immuno- chemical Studies, p. 227, London, Constable 1925.—(17) Reiner et al. Z. Immun, forsch. 61 (1929) 317, 397, 459.—(18) Rruyt: Kolloid Z. 31 (1922) 338.—(19) Neufeld and Etinger-Tulczynska: Zbl. Bakter. 114 (1929) 252. —(20) Freund: J. Immun. 21 (1931) 127; Proc. Soc. Exp. Biol. a. Med. 28 (1931) 1010.—(21) Hirschfeld: Arch. f. Hyg. 63 (1907) 237.—(22) Rotier: Die Saponine. Wien, Springer, 1927.—(23) Ponder: Biochem. J. 24 (1930) 805.—(24) Topley et al.,: Br it. J. Exp. Path. 16 (1935) 116.—(25) Abram- son: Nature 135 (1935) 995. (26) Rraus and Werner: Giftschlangen, Jena, Fischer 1931.