Requirements for food R&D, 1994 / MAFF.

  • Great Britain. Food Safety Directorate
Date:
1993
Catalogue details

Licence: Open Government Licence

Credit: Requirements for food R&D, 1994 / MAFF. Source: Wellcome Collection.

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    13. | Wherever possible research proposals should involve in vivo experimentation rather than in vitro, and focus on effects in man rather than in animal models. ANTIOXIDANTS IN FOOD SPECIFIC RESEARCH REQUIREMENTS 14. There are no plans to invite further work in this area in the coming year. DIETARY LIPIDS Metabolic Effects of Triglyceride Structure 15. There are a number of ongoing projects in the dietary lipids programme which are investigating the physiological effects of individual fatty acids and fats of differing fatty acid composition. However, people do not ingest mixtures of free fatty acids but rather mixtures of triglycerides. The three positions on glycerol are not metabolically equivalent and randomisation of the fatty acids in butter abolishes its hypercholesterolaemic effect. This type of experiment suggests that triglyceride structure is at least as important as triglyceride fatty acid composition in determining metabolic effects but information in this area is sparse. - Proposals are sought on the effects of differences in structure on triglyceride absorption, metabolism, transport and tissue uptake in man. Dietary Lipids and Haemostasis 16. | Haemostatic mechanisms in humans appear to respond much quicker to dietary manipulations than atherosclerotic mechanisms. Since Health of the Nation targets are to be met by the year 2005, it would seem more sensible to attempt to meet these targets using dietary interventions which work via haemostatic mechanisms. This area of research has been neglected in favour of effects of nutrition on atherosclerotic mechanisms. - Studies on the effects of and mechanism of action of individual saturated, monounsaturated and polyunsaturated fatty acids and fats with different fatty acid compositions on cells and tissues involved in the process of thrombosis, fibrinolysis and other haemostatic mechanisms in man are sought. Dietary Fatty Acids and Insulin Sensitivity 17. Insulin sensitivity is associated with good health. Insulin resistant states such as obesity and non insulin dependent diabetes are associated with hypertension, hyperglycaemia and hypertriglyceridaemia, all of which are risk factors for coronary heart disease. Loss of body weight which improves insulin sensitivity lowers blood pressure, blood glucose and blood triglycerides. There are indications in the literature that certain dietary fatty acids can improve insulin sensitivity.
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