Studies on Rocky Mountain spotted fever / U.S. Treasury Department, Public Health Service.

Date:
[1930]
Catalogue details

Licence: Public Domain Mark

Credit: Studies on Rocky Mountain spotted fever / U.S. Treasury Department, Public Health Service. Source: Wellcome Collection.

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    OL ical rash. A spleen emulsion of monkey No. 10 produced typical fever and symptoms when injected into guinea pigs. The eight vaccinated animals remained well. TABLE 15.—Vaccine No. 210—Vaccination of M. rhesus [Vaccine prepared February 19, 1925; injected subcutaneously. Titer=1/5,000 tick] First dose Second dose Immunity test No.| Feb. 25, 1925 | Mar. 2, 1925 Mar. 12, 1925 Result MeO OnUOl 2 2a. 1S8 oe 2 1c. c. blood virus.| Mar. 25, 1925.—Dead. Typical spotted fever and rash. 7A GOR. a A Se ee an ee Ge ese ee Do. 4 Bee (AV SE OS Se OE TREE, eed Sie | creas Cbewss 552 SE Mar. 22, 1925.—Dead. Typical spotted fever and rash. LLB) OB Gy Roe 2 Sel Oe Oe See eee eae me lip kage Cees ge Apr. 4, 1925.—Active and healthy. 1a eee (Oo ee 38 ee nee (ree 70 (ee, eeeeeernal Do. (ee eae derves.2t i: SRC ara Cee Es el PEERS AGsctke sei 3. Do (ial ear AOe se. DEO. Caren fa |e Gees ee. Do ee ae 6 VR See WS ae ap. .tes Sibien3 dose es: Do TABLE 16.—Vaccine No. 219—Vaccination of capuchin monkeys [Vaccine prepared March 21, 1925; injected subcutaneously. Titer=1/1,000 tick] N First dose Second dose Immunity test Mar. 25, 1925 | Apr. 1, 1925 Apr. 11, 1925 Result Be pone be, Fa Deis eae ieee he ie ce. tick virus_| Apr. 21.—Dead. Typical spotted fever. ee Otte ool oS 2 oh Omen emer ean 0. PI SAIC. Com VAC W125. .C5.Cs, VaG=. (pe. - | Gonee= oe mek Remained well; discharge June 1. cine: cine. 2 4e\ ce 8G 5 a Meares ae Se | tie (0 ko ee eek sae Pe ee 0 Ge ue Seestae eee Do 12 i ae GOP hess 2 NESS 0G re lee ny pel Lae GO -nwecctece Do EXPERIMENTAL VACCINATION OF MAN In investigations of Rocky Mountain spotted fever or other disease transmitted by insect vectors, no attempt has been made, so far as we are aware, to protect man by inoculating material from an inter- mediate host. Breinl (Breinl, 1924) has shown that guinea pigs may be protected against typhus fever by injecting phenolized emul- sions of infected lice, but the method was not applied to man. Up to the present time a total of 34 people, chiefly laboratory and field workers in Rocky Mountain spotted fever and others whose occupations expose them to infection, have been vaccinated. Each lot of vaccine for human use was first tested for sterility, following the Hygienic Laboratory technique required for biologic products, and for protective ay and harmlessness by injection into guinea pigs. The vaccine was administered subcutaneously in doses of 1 or 2 ce. c. each at 5-day intervals. Some have received 2, some 8, and some 4 injections. No severe reactions have been encoun- tered. The total number of M. I. D. for guinea pigs per vaccinated individual has varied from 2,000 to 17,500. The greatest number
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