Genetic control of immune responsiveness : relationship to disease susceptibility / edited by Hugh O. McDevitt and Maurice Landy.

Date:
1972
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetic control of immune responsiveness : relationship to disease susceptibility / edited by Hugh O. McDevitt and Maurice Landy. Source: Wellcome Collection.

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    GENETIC CONTROL OF IMMUNE RESPONSIVENESS cule of BSA being indicated by a subscript following the DNP. GPA Guinea pig albumin. DNP-GPA Guinea pig albunnin substituted with dinitrophenyl groups. HSA Hunnan serum albumin. (T,G)-A—L A branched, multichain copolymer of the general struc¬ ture shown in Fig. 20 of Session II. The copolymer has the structural formula: poly-L- (tyrosine, glutamic acid)-poly-D,L-alanine—,poly-L-lysine. The structural formula is written this way to indicate that the amino acids in parentheses are in random sequence, the dash indicated a long stretch of poly-D,L-alanine, and the double dash indicated a branch point where the alanine joins the epsilon amino groups of lysine which forms the backbone of the molecule. Thus, the synthetic poly¬ peptide is built on a chain of poly-L-lysine with each lysine being substituted in its epsilon amino group by a long side chain of alanine, attached to the amino termi¬ nus of which is a short random sequence of tyrosine and glutamic acid. (H,G)-A—L Poly-L(histidine, glutamic acid)-poly-D, L-alanine- poly-L-lysine. Structural analog of (T,G)-A—L in which the tyrosine is replaced with histidine. (Phe,G)-A—L Poly-L(phenylalanine, glutamic acid)-poly-D, L-ala- nine--poly-L-lysine. A structural analog of (T,G)-A--L in which the tyrosine is replaced by phenylalanine. (T,G)-Pro--L Poly-L{tyrosine, glutamic acid)-poly-L-proline—poly-L- lysine. This synthetic polypeptide has the same general structure as (T,G)-A—L and its congeners, but in this case, the side chains of poly-D, L-alanine are replaced with poly-L-proline. (Phe,G)-Pro~L Poly-L(phenylalanine, glutamic acid)-poly-L-proline— poly-L-lysine. A structural analog of (T,G)-Pro—L in which the tyrosine is replaced with phenylalanine. 4
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