Experimental investigation into the disease, produced by the inoculation of the bacillus pyocyaneus / by M. Armand Ruffer.

  • Ruffer, Sir Marc Armand, 1859-1917.
Date:
1889
Catalogue details

Licence: Public Domain Mark

Credit: Experimental investigation into the disease, produced by the inoculation of the bacillus pyocyaneus / by M. Armand Ruffer. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    the venous circulation of each of these two rabbits and of two other non-vaccinated animals, it was found that the two latter animals died within twenty-four hours, whereas the two other rabbits are alive to this day, more than two months after the inoculation. Not satisfied with this result, we tried to see whether the vaccination was perfect and lasting. Accordingly, nine days afterwards, we reinoculated the same two rab- bits with the most virulent culture at our disposal, and they again came safely through the ordeal, another non- vaccinated animal inoculated at the same time, with the same dose of the same culture, dying in less than twenty- four hours. Since then these experiments have been repeated by us on fourteen other rabbits, with the result that the animals previously subjected to the injections of the filtered and heated extract of blood of pyocyanic animals resisted the introduction of the bacillus pyocyaneiis into their system ; whereas the other rabbits—and we always inoculated another rabbit at the same time and with the same cul- ture—died within forty-eight hours. It must, however, not be thought that these animals were efficiently vaccinated. The fact is, that although the rabbits previously subjected to the injection of the sterilised blood did not die within forty-eight hours of the injection of the bacillus as did the non-vaccinated animals, they most of them perished seven to fourteen days after the inoculation of the bacillus—all except three alive now,
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