Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry.

  • Terry, B. T. (Benjamin Taylor), 1876-
Date:
1911
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Licence: In copyright

Credit: Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

    54/78 (page 50)
    less marked resistance to caderas, srirra of Mauritius, and surra of India was manifested by mice immunized to dourine, the latter species was in one respect clearly dififerentiated from all of the others, for in every mouse inoculated with dourine, infection was delayed one or more days. On the other hand, trypanosomes ap- peared within twenty-four hours in at least one of the tests with each of the other species, and in the three with nagana (mice 9, 14, and 19), not a trace of resistance was detected. DOUBLE IMMUNITY. When mice infected with both surra of India and surra of Maur- itius were cured, they acquired a double immunity. 1. SI+SMi-;* oCLoisol 5 'SSL'-;* It-H 0 2. SI+SMiiV* ^'AA• 5 'SSIDSll^-^i' it-ai 0 'D. 3. SI+SMi^-T oOLoIsol 10 'SSIf-^J l*-Si 0 4. SI+SM.-r IAa 10 l«-Sf 0 5. SI+SMfA' 19 cSI+SMi-r 0 MQ OM si+smr ;aa'- oOLoIwl 5 oUDl-4 ♦ This is shown by the fact that no infection took place when the animals were tested with surra of India (mice i and 3), with SI[M] (mouse 2), with surra of Mauritius (mouse 4), or with a mixture of surra of India and surra of Mauritius (mouse 5). There was, however, little or no immunity to caderas (mouse 6), for this animal was positive twenty-four hours after its control. ON THE SEPARATION OF ORGANISMS MIXED IN VITRO.^'^ Trypanosomes mixed in vitro can apparently be separated by means of the immunity reaction. In order to do this, the mixture of parasites is inoculated into mice immunized to one of the strains. Under these conditions, infection takes place with the trypano- somes against which no immunity was produced. In the following experiments the attempt was made to separate The experiments here reported should not be confused with those of Brown- ing in which strains of trypanosomes rendered resistant to various medicaments w-ere separated after being mixed in vitro. Browning {Brit. Med. Jour., 1907, ii, 1405) effected the separation, not by immunity, but by treating a double infection in mice with a medicament against which the trypanosomes of one of the infec- tions were resistant.