Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry.

  • Terry, B. T. (Benjamin Taylor), 1876-
Date:
1911
Catalogue details

Licence: In copyright

Credit: Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

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    With surra of Mauritius two inoculations (Nos. 3 and 6) were made. Following one of these (No. 3) infection was only slightly delayed, the parasites appearing forty-eight hours after the first test. After being positive for one day, however, this mouse re- covered completely. In the second animal injected with surra of Mauritius (No. 6), the appearance of the parasites was greatly delayed, the incubation period being eleven days (control one day). With SM[I] only one test (mouse 4) was made. In this, infec- tion took place at once, but subsequently the animal became nega- tive and was not killed by the parasites until the seventeenth day after inoculation. In view of zvhat has already been said about the relationship of surra of India and surra of Mauritius, the re- sistance shozvn by the third, foiirth, and sixth mice is not surprising and can not be taken to prove that the separation of surra of India from surra of Mauritius zvas not effected in purity. Purity of SM^I}.—The experiments with SM[I] resulted as follows:— (1) Mice immunized to surra of Mauritius zvere immune to SMUy 3, SMsVr. \^^' lO\Xm^ 15 cSM[I]f4' ^'i D.'^ Of the three animals inoculated, only one became infected and this (No. ,3) was tested on the fifteenth day. Even then it had a strong immunity, for it did not become positive until the twelfth day after inoculation (control infected on the first day). (2) Mice immunized to surra of India were not immune to sum. 3. SL^.' lO\S^o 6 isMm' '-^ D, 4. sif^f :cLi^5„L 10 'isM[i]e''r D, 5. sr^. iCJi-^L 10 'isMffl/'i D, Every one of the five animals became infected and in only two (Nos. 4 and 5) was the appearance of the parasites delayed. In these two cases, the trypanosomes introduced were very few, not 4-8