Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry.

  • Terry, B. T. (Benjamin Taylor), 1876-
Date:
1911
Catalogue details

Licence: In copyright

Credit: Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

    68/78 (page 64)
    1. SERUM[I+M]ri.^r + SM^^?-^ 'o L. The above means that the serum employed came from the goat immunized to both surra of India and surra of Mauritius. Of this serum .75 c.c. (one day old) was mixed with .25 c.c. of a suspension containing three parasites in ten fields. The mixture was then injected subcutaneously into a mouse, and a similar quantity of virus (without serum) was introduced into another animal. The former remained negative from the third to the thirty-first day and was still living on the sixtieth day, while the latter became positive on the third day and was dead on the seventh. When the serum from a single bleeding was used on different days, it was kept in the ice chest in the intervals between tests. Goat I.—The experiments with the serum of Goat i follow. GOAT 1 BLED JUNE U 1907 1. SERUM[I+M]fDAv + SMa^r^ '0 L. 2. SERUM[I+M]i^Y + SMf^?^ 0' L. 3. SERUM[I+M]foAY + SM^^-' 0 D.°'* 4. SERUM[I+M]fD/v + Sli-r '0 «*L. SERUMtl+Ml/DAv + SIIT '-i L. r.2s.005 0, 6. Serum[I+M].day + sii-r '-0 -L. 7. SERUM[I+M]fDXv8 + Sltl' ^L. 8. SerumCI+MJ^^^ms + SB '-o L. 9. SERUMri+M]f»?vs + 'D.'- From the above it is evident that the serum of this goat exerted a strong preventive action against the two strains of surra of India and surra of Mauritius employed in my experiments. Of the nine mice tested, only one (No. 9) became infected and this animal re- ceived the minimum quantity of serum and a comparatively large number of trypanosomes. Even in this case, however, there was some protection, for the incubation period was seven days, that of its control two days. Qoat 2.—Goat 2 was twice bled. As the results of the two bleedings are very much alike, they will be considered together, the experimental evidence for both being given on page 65. The tests with the serum of this goat seem to indicate that no contamination of virus had taken place in the strains used in my experiments, and show clearly the very close relationship between