The direct action of nicotin upon the mammalian heart / by Henry G. Beyer.

  • Beyer, Henry Gustav, 1850-1918.
Date:
[1900]
Catalogue details

Licence: In copyright

Credit: The direct action of nicotin upon the mammalian heart / by Henry G. Beyer. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    revolving drum were, of course, counted and measured from one and the same record. This record was made by means of a Hurthle membrane-manometer connected with a rectangular glass tube, one end of which had been introduced into the left ventricle, through the left auricular appendix and mitral valves. The record, moreover, made by this piece of apparatus, while, of course, merely recording the number of ventricular contractions and the intra- ventricular pressure, would also furnish an indication of the rela- tive amount of work done by the left ventricle. The pressure, under which the blood was forced into the coronary arteries, was uniformly fixed at 95 mm. of mercury, except during the period of recovery of the heart from the operation, when it was slightly lower. July 13, 1899. Cat’s Heart. Undiluted Defibrinated Dog’s Blood. Nico- tinized Blood 1: 10,000. Temperature of Blood 39° in the Beginning, 34° C. at end of Experiment. Time. P. M. No. of Drops. No. of Pulsations. Amplitude Remarks in mm. Remarks. i. 5-6 36 208 10-12 6-7 40 206 10-12 On poisoned blood. 7-8 64 140 25-35 8-9* 65 210 25-40 On normal blood for five minutes. 14-15 36 88 18 Auricles beat twice to ventr. once. 15-16 41 80 18 On poisoned blood. 16-17 42 82 18-30 18-19 47 118 38 On normal blood. 19-20 27 110 18 22-23 24 70 10-12 Auricles twice to ventricles once. 24-25 20 54 12 Accident to blood supplying app ended up. Nicotin (Mercks’) when used in the proportion of one to twenty- five thousand, as shown in this experiment, diminishes the volume of the coronary circulation, an effect which even a prolonged flow of normal blood through the heart does not seem able to overcome entirely. The number of beats in a given time seems at first very slightly increased, but quickly returns to the normal or falls even below that. As the heart’s action grows more feeble under the prolonged influence of nicotinized blood, the auricles beat more frequently than the ventricles, a condition, however, which is changed by the readmission of nicot. blood, but returns on normal blood being turned on again. The amplitudes of the intraven-
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