A contribution to the pathology of paramyoclonus multiplex (Friedreich's type) / by J. Ramsay Hunt.

  • Hunt, James Ramsay, 1872-1937.
Date:
1903
Catalogue details

Licence: In copyright

Credit: A contribution to the pathology of paramyoclonus multiplex (Friedreich's type) / by J. Ramsay Hunt. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Many of those remaining were below the normal standard, so that the contrast was very evident. Another peculiarity was the presence of sarcolemma nuclei between the sarcous elements. This is a peculiarity of the so- called red fibers of the lower vertebrates, a form of muscle which is more active, and capable of more prolonged contraction, than the white fibers which constitute human muscle, although such red fibers are scattered in very small number throughout the muscular system in man. It is interesting and significant to observe that changes similar to those just mentioned have been described in cases of myotonia congenita (Erb,35 Dejerine and Sottas36), the hypertrophic stage Fig. 5—Sartorius muscle from a case of chronic progressive chorea [control preparation]. Same enlargement as Fig. 3. of the muscular dystrophies, and in those rare cases of true mus cular hypertrophy, of which examples have been described by Friedreich,37 Auerbach,38 and Berger39. If such alterations in the size and nuclear constituents of the muscle fiber were simply the result of overaction, and secondary only to violent and prolonged muscular action, they should occur in long-standing spasmodic affections of cerebral origin. In one of the cases used as a con- trol preparation in the present study, a chronic progressive chorea