Mandelic acid B.D.H. : sodium mandelate B.D.H. for use in the treatment of urinary infections as a substitute for a ketogenic diet / The British Drug Houses Ltd.
- British Drug Houses
- Date:
- [1935?]
Licence: Public Domain Mark
Credit: Mandelic acid B.D.H. : sodium mandelate B.D.H. for use in the treatment of urinary infections as a substitute for a ketogenic diet / The British Drug Houses Ltd. Source: Wellcome Collection.
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![Bacterio- static power of mandelic acid Necessity of maintenance of pH of urine at 5°3 or below Mandelic acid admin- istered as Sodium Mandelate B.D.H. Method of treatment of twelve cases 6 MANDELIC: AGI DSB, DH: produce an effect similar to that produced by the ketogenic diet ; thus this somewhat irksome form of treatment might be replaced by a more simple therapy. The result of the investigation demonstrated that the bacterio- static power of mandelic acid compared favourably with that of B-hydroxybutyric acid, and that, in general, it fulfilled the desiderata of a satisfactory urinary antiseptic. When tested in vitro it was found that it possessed marked bacterio- static powers against B. coli, and that urine passed three hours after the administration of mandelic acid would not support the growth of this organism at a low pH. In mandelic acid therapy (as with the ketogenic diet) clinical improvement is possible only when the pH of the urine is maintained at a favourable point— 5-3 or below. This is best effected by the oral administration of ammonium chloride, and the most suitable indicator for use in deter- mining the pH of the urine has been found to be methy] red. For therapeutic use, mandelic acid is always administered as the sodium salt. The sodium salt of Mandelic Acid B.D.H. is issued in the form of tablets (wde page 10); it is supplied also in bulk as the pure crystalline salt, Sodium Mandelate B.D.H. Pure crystalline Mandelic Acid B.D.H. (for neut- ralisation with sodium bicarbonate) is also available in bulk. CLINICAL APPLICATION Further experimental work having demonstrated its non- toxicity, mandelic acid was subjected to clinical trial in twelve cases of urinary infection, six of which were cases of pyelitis of pregnancy ; the routine method of treatment adopted was to give, in divided doses, 12 grammes daily of mandelic acid in the form of its sodium salt. The standard mixture used contained 3 grammes (45 grains) of](https://iiif.wellcomecollection.org/image/b33459198_0006.jp2/full/800%2C/0/default.jpg)
