Volume 2

The extra pharmacopœia of Martindale and Westcott.

  • Martindale, William, 1840-1902.
Date:
1912
Catalogue details

Licence: In copyright

Credit: The extra pharmacopœia of Martindale and Westcott. Source: Wellcome Collection.

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    The identification of Cocaine and some Cocaine substittues. Cocaine Salts and substitutes will react under certain conditions with Gold Chloride, Platinum Chloride, Chromic Acid and Potassium Permanganate to form precipitates which, when examined under the microscope, are found to possess definite and characteristic crystalline forms. The Alkaloid, isolated in the usual way, is converted into the Hydrochloride and made up to a I % solution and tested under definite conditions.—Am. Jl. P.h 1911, p. 195. 136. Codeine Hydrochloride.—Does not reduce Iodic Acid (Morphine does). No blue color with Ferrioyanide and Ferric Chloride (Morphine gives)—c./. Allen, vol. HI., 2, p. 321, and Schmidt, vol. II., p. 1510. O’l grm. warmed with about 1 Cc. Sulphuric Acid and 1 drop of Fe2Cl6 solution gives deep blue color. Greenish blue with Frohde’s Reagent. 137. Colchicine.—Only slightly soluble in Ether or Benzol. Practically insoluble in Petrol Ether. H2SO4 with a trace of HNO3 added gives yellowish green changing to blue violet and wine red to yellow. (Dragendorff). Cl water gives yellow precipitate with an aqueous colchicine solution soluble in NHg with orange color.—c.f. Allen, vol. III., 3, p. 4. Also Schmidt, vol. II., 2, p. 1412. NaNO^+HC1 give dirty brown pp. 140. Conium Bases.—See also p. 30. 145. Cnbebin.—With K2Mn203 in alkaline solution oxidised to Piperonylic Acid and Oxalic Acid.—Schmidt, vol. II., 2, p. 1669. 147. Dermatol.—NaOH dissolves it with yellow color—turning red. 148. Dextrose.—[aj^ = 4- 104® for the pure article in fresh solution. For the Hydrate [a]D =+90 to 96®. Aqueous solutions of silver are reduced especially when warmed. In addition to Feh- ling’s, Barfoed’s Reagent (warm) is also reduced (distinction from Dextrin and Maltose). Sodium, Calcium and Barium Oxides form saccharates soluble in water. Ferments with yeast (useful confir- matory test). 149. Digitoxin.—HCl Sp. Gr. 1T9 dissolves it in the cold with- out coloration, but on warming it dissolves with brownish color.— cJ. jSchmidt, vol. II., 2, p. 1640 for other special tests. 150. Dionine.—Does not give blue color with Ferric Chloride or reduce lodates direct. 0 01 Gm. Dionine dissolved in 10 Cc. Sul- phuric Acid after liberation of the HCl from the compound gives a clear solution which, on adding a drop of Ferric Chloride solution and warming turns violet to deep blue, changing to deep red on- adding 2 to 3 drops of Nitric Acid. The free base (Ethyl Morphine) is less soluble in Ammonia than Codeine, Such solution reprecipis tates the base in prismatic crystals melting at 93®C. Dionine is distinguished from Morphine in that, on adding it to a solution of Potassium Ferri-cyanide with Ferric Chloride, it does not give an immediate blue; but gradually a bluish green color.—Hager,