Note on the effect of temperature upon the action of thrombin and antithrombin / by W.H. Howell.

  • William Henry Howell
Date:
[1914?]
Catalogue details

Licence: Public Domain Mark

Credit: Note on the effect of temperature upon the action of thrombin and antithrombin / by W.H. Howell. Source: Wellcome Collection.

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    December, 1914 NOTE ON THE EFFECT OF TEMPERATURE UPON THE ACTION OF THROMBIN AND ANTITHROMBIN W. H. HOWELL From the Physiological Laboratory, Johns Hopkins University Received for publication October 5, 1914 The main object of this note is to call attention to the marked augmenting effect of temperatures at or above the body-tempera- ture upon the activity of antithrombin, and also to emphasize one important condition influencing the effect of high tempera- tures upon thrombin. . The effect of variations in temperature upon the time of coagu- lation has been studied by a number of observers, both as re- gards the clotting of normal blood and the coagulation of artificial plasmas or fibrinogen-solutions. In the case of normal blood the conditions are quite complex since several distinct processes come into play and these processes may be affected differently by the changes of temperature, the actual time of clotting being the resultant of: their interaction. We have to consider, for instance, such changes as the disintegration of the platelets, the activation of the prothrombin, the neutralisation of the antithrombin and the final reaction between the thrombin and the fibrinogen. In consequence, perhaps, of this complexity of processes, and also because of the different methods employed, the results reported by different observers for normal blood have not been entirely concordant. All observers agree that between 1
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