The physiological effects of peptone and its precursors when introduced into the circulation : interim report ... / E.A. Schäfer [and others].

  • Sharpey-Schäfer, E. A. (Edward Albert), Sir, 1850-1935.
Date:
[1898]
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Licence: Public Domain Mark

Credit: The physiological effects of peptone and its precursors when introduced into the circulation : interim report ... / E.A. Schäfer [and others]. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    Section T.—Toronto, 1897.] 2%e Physiological Effects of Peptone and its Precursors when introduced into the Circulation.—Interim Report of a Committee, consisting of Professor E. A. Schafer, F.R.S. (Chairman), Professor C S Sherrington, F.R.S., Professor E. W. Boyce and Professor W. H. Thompson (Secretary). (Prawn up by the Secretary.) The present report is to be regarded as a continuation of work the first results of which were communicated by the Secretary of this Committee to the British Association (Section I) at its meeting in Liverpool last year, and afterwards published in the ' Journal of Physiology ' vol xx December 1896, p. 455.1 5 The chief conclusions then arrived at concerned the effects of Witte's 'peptone,' and were—(1) That this substance in small doses—below 0-02 grm. per kilo-hastens the coagulation of blood in the dog, while in larger doses retardation is brought about, as other investigators have tound. (2) That the well-known fall of blood-pressure produced by this substance when injected into the circulation is due to a peripheral influ- ence upon the neuro-muscular apparatus of the blood-vessels. No influence on the vaso-motor centre was detected. (3) That the vaso- di atmg influence of Witte's < peptone' is not confined to vessels of the splanchnic region, but extends to other vessels also. This last conclusion was arrived at in an indirect way by observing the eftects of Witte's 'peptone ' on carotid blood-pressure when injected during excitation of the spinal cord (after complete section), at the level of the third cervical vertebra, the great splanchnics on both sides having been previously divided Neither time nor circumstances had then permitted the checking of this result by similar injections made during excitation ot the sciatics, nor of the observation of plethysmography variations of limb volume under similar conditions of experiment Accordingly, in the work carried out during the past year which has been entrusted to ^e Secret this was ^ fir* P to ^ ™^ was given. A similar method of observation was then applied in turn to snfeen T, WltWS '^T' °U ^ blood—^ o/The kidney and coacfulatil Mr SUCC6edeC h* a» analvsis of the effects (a) on blood- coagulation (6) on general blood-pressure and peripheral vaso-motor mechan^u, (c) on local vascular areas (limb, kidney, spleen) of the follow- ing substances-pure peptone, anti-peptone, cleuteio-albumose nroto tllZTs is af tf ^ V? ^ as regards X latte'rto substances is as yet too incomplete for publication, nor indeed can it he TtTnnt:\m°7Sanpreliminary f°r W °f the -bstances men oned follows :- PreSent ab3traCfc ^ theref01'e b« summarised as I. Hffects of Witte's peptone— (?) ^n the blood-vessels of the limb ; \ rln the blood-vessels of the kidney • (c) On the blood-vessels of the spleen. ' i 4 1^.