A note on the inhibitory effect of monoiodoacetic acid on lactic acid production by cancer tissue / by Sylvia Thurlow Harrison and Edward Mellanby.

  • Harrison, Sylvia Thurlow.
Date:
[1931?]
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Licence: In copyright

Credit: A note on the inhibitory effect of monoiodoacetic acid on lactic acid production by cancer tissue / by Sylvia Thurlow Harrison and Edward Mellanby. Source: Wellcome Collection.

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    Table II. Aerobic glycolysis of tumour slices after injection of iodoacetic acid. Animal A ... Animal B ... Animal C ... Control Lactic acid per g. dry weight tissue ms. 48-8 56-5 12-9 37-0 The figures for the tumour glycolysis of the injected animals are an average of three experiments done on each tumour. These results, although varying considerably from the control, at least indicate that when the dose of iodoacetic acid is sublethal, there is no inhibitory effect upon lactic acid production of the tumour after a single injection, but when the dose causes acute symptoms of poisoning, the lactic acid production of the tumour is strongly inhibited. Summary. 1. The aerobic production of lactic acid by tumour slices is inhibited by iodoacetic acid. 2. A few experiments, on mice, in which a single injection of iodoacetic acid was given, show that no inhibition of lactic acid production in tumour occurs provided that the dose is sublethal. We are indebted to the Yorkshire Cancer Research Fund for the expenses incurred in carrying out this work. REFERENCES. Friedemann, Cotonio and Shaffer (1927). J. Biol. Chem. 73, 335. Harrison and Mellanby (1930). Biochem. J. 24, 141. Lundsgaard (1930, 1). Biochem. Z. 217, 162. - (1930, 2). Biochem. Z. 220, 8.