The differential blood count in dengue / by W.L. Harnett.

  • Harnett, W. L.
Date:
1913
Catalogue details

Licence: Public Domain Mark

Credit: The differential blood count in dengue / by W.L. Harnett. Source: Wellcome Collection.

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    increased from the diminution of the polymorpho- nuclears, show an absolute increase towards the end of the week. The distinction between large ard small lymphocytes in this disease is rather arbitrary, as all sizes are met with from 6uy—12y. A common variety met with in this disease is slightly larger than the ordinary small lymphocytes with a round or slightly indented nucleus, placed a little eccentrically, with a clear blue protoplasm (Leishman’s stain) containing several coarse basophil granules. These cells are often met with in malarial bloods, but are especially common in this disease and are evidently associated with the lymphocytic increase which oceurs towards the end of the week. The difficulty in classifying them is increased by the fact that owing to the leucopenia, the differential eount has to be done at the edges of the film where the cells are always liable to be distorted and hard to recognise. Tn addition to these wellreeognised changes there occurs also another, which, as faras 1 know, has not hitherto been described m dengue, and to which it is the purpose ef this paper to draw attention. This change consists in a variable amount of eosinophilia always present, and, sometimes dominating the whole blood picture, which sets in about the 4th—6th day and is well marked by the 10th day, and persists for some time afterwards. In the following 12 cases the first blood count was done during the febrile stage, and a second and in some cases a third and fourth during the convalescent stage. No. I. Indian. Fever lasted 3 davs, no rash. Chart No. VIL. Ist Count, 31st July, 1912, 2nd day— Polymorphonuclears ... 61 per cent. Large Monouuclears ... 3°5 per cent. Large Lymphocytes ... 16 ,, i =33°5% Small Lymphocytes ...175 ,, ae 5 Eosinophiles Bee bl Dare 5 2nd Count, 9th August, 1912, 11th day— Polymorphonuelears ... 37°5 per cent. Large Mononuclears ... 2 oe Large Lymphocytes »« 17 ,, ~35°5% Small Lymphocytes ... 18°5 - . Eosinophiles woe =. s Leveopenia marked in both films.
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