The chemical and physiological assay of digitalis tinctures / by George Barger and W. Vernon Shaw.

  • Barger, George, 1878-1939.
Date:
[1904?]
Catalogue details

Licence: Public Domain Mark

Credit: The chemical and physiological assay of digitalis tinctures / by George Barger and W. Vernon Shaw. Source: Wellcome Collection.

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    Tincture. Dose. Weight of Frog in Gm. Result. IV. 0 4 c.c. 24 died, 110 minutes. 25 died, 100 minutes. 0 3 c.c. 23 died, 180 minutes. 22 lived. 0-2 c.c. 22 lived. 22 lived. M.L.D. @= 0 35 c.c. for 23 Gm. frog. V. 0-4 c.c. 36 died, 120 minutes. 32 died, 100 minutes. 29 died, 100 minutes. 29 died, 100 minutes. 0 3 c.c. 26 died, 120 minutes. 26 died, 150 minutes. 28 lived. 30 lived. 0'25 c.c. 29 lived. 29 lived. M.L D .— 0-35 c.c. for 27 Gm. frog. VI. 0-4 c.c. 25 died, 130 minutes. 24 died, 120 minutes. 0-3 c.c. 25 lived. 23 lived. M.L.D. — 0-4 c.c. for 24 Gm. frog. VII. 0-6 c.c. 33 died, 140 minutes. 32 died, 120 minutes. 0-5 c.c. 25 died, 120 minutes. 26 died, 140 minutes. 32 lived. 34 lived. M.L.D. = 0-5 c.c. for 29 Gm. frog. VIII. 0 25 c.c. 21 died, 120 minutes. 20 died, 90 minutes. 20 died, 120 minutes. 24 lived. M.L.D. = 0 25 c.c. for 22 Gm. frog. IX. 0-4 c.c. 25 died, 100 minutes. 23 died, 100 minutes. 0-3 c.c. 20 died, 120 minutes. 23 lived. 20 lived. M.] -j.D. = 0-33 c.c. for 22 Gm. frog. The preceding tables are summarised below. The M.L.D. for 100 Gm. of frogs has been calculated on the supposition (not verified) that the dose for frogs is proportional to their weight.