The action of tetrahydropapaveroline hydrochloride / by P.P. Laidlaw.

  • Laidlaw, Patrick Playfair, 1881-1940.
Date:
1910
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: The action of tetrahydropapaveroline hydrochloride / by P.P. Laidlaw. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [.Reprinted from the Journal of Physiology, Vol. XL. No. 6, August 15, 1910.] THE ACTION OF TETRAHYDROPAPAVEROLINE HYDROCHLORIDE. By P. P. LAIDLAW, M.A., B.C. (From the Wellcome Physiological Research Laboratories.) Tetrahydropapaveroline hydrochloride is a new alkaloid which was made recently by Pyman(I) during his study of the reduction products of papaverine. It presents some features of interest owing to its well- marked physiological action. The effects it produces on the normal animal are such as hold out the hope of its value as a therapeutic agent and on that account an investigation of its physiological actiou seemed desirable. Its relationship to papaverine is shown in the following structural formulas: CH Papaverine Tetrahydropapaveroline Details of its chemical properties and relationships will be found in Pyman’s paper. It may be mentioned that its hydrochloride is a white crystalline solid slightly soluble in water or saline solution. It is readily oxidised, and an alkaline solution in contact with air slowly assumes a fine purple colour and ultimately deposits a purple black amorphous precipitate. Fehling’s solution and ammoniacal silver nitrate solutions are readily reduced by it. The intact animal. On the intact animal very few effects are observable because the action of the alkaloid is not of such a kind as produces grave disturbances of the normal processes. It is moreover 31 PH. XL.