Genetic studies in mental subnormality.

Date:
1973
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Genetic studies in mental subnormality. Source: Wellcome Collection.

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    families where siblings have similar clinical abnormalities 65 Table II Summary of data on families in Group С Unexamined siblings: M = males, F = females, parentheses denote death. E.E.G. : G = generalized abnormality, T = temporal focus, S = slow wave excess, SD = Spike and dome, N = normal, nd = not done, NK = not known, SN = subnormal, Epi = epilepsy, Psych. = psychosis. in its course and clinical manifestations. The parents were first cousins and Jewish. Permission for full investigation, including biopsies, was not granted. In the remaining 6 families in Group D the clinical features are such that it has not been possible to allocate them to a known syndrome or broad group of disorders. The like features in each sibship are, however, sufficiently consistent and abnormal to make it probable that they are caused by the same genetic defect or defects. Case Reports Family 2—Cerebral diplegia, brachydactyly The sibship consists of a sister aged 61 (index case 4), who has died, a brother aged 59- (index case 5), a sister aged 56 (index case 6), and a younger normal sister who has four unaffected children. The parents were normal and unrelated. The affected siblings have I.Q.s of 40, 41 and 45. All have cerebral diplegia which is mildest in the eldest and most severe in the youngest; the eldest is able to walk, the second able to