Factors affecting the coagulation time of blood. IV, The hastening of coagulation in pain and emotional excitement / by W.B. Cannon and W.L. Mendenhall.
- Walter Bradford Cannon
- Date:
- [1914?]
Licence: Public Domain Mark
Credit: Factors affecting the coagulation time of blood. IV, The hastening of coagulation in pain and emotional excitement / by W.B. Cannon and W.L. Mendenhall. Source: Wellcome Collection.
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![Reprinted from the American Journal of Physiology Vol. XXXIV — May 1, 1914 —No. II FACTORS AFFECTING THE COAGULATION TIME OF BLOOD IV. THe HASTENING OF COAGULATION IN PAIN AND EMOTIONAL EXCITEMENT By W. B. CANNON and W. L. MENDENHALL [From the Laboratory of Physiology in the Harvard Medical School] Received for publication March 30, 1914 N the preceding paper of this series evidence was given to prove that stimulation of splanchnic nerves, with accompanying increase of adrenal secretion, results in more rapid clotting of blood. Recent experiments have shown that certain conditions — such as pain and emotional excitement — likely to arise in the natural life of organisms and known to be attended by nervous discharges over splanchnic courses, are also attended by increased secretion of adrenalin into the blood.! Does the adrenalin thus liberated have any effect on the rate of coagulation? The observa- tions here recorded were made in order to obtain an answer to that question. The effect of “painful” stimulation.—In experiments on the action of stimuli which in the unanaesthetized animal would cause pain, faradic stimulation of a large nerve trunk (the stump of the cut sciatic), and operation under light anaesthesia, were the methods used to affect the afferent nerves. Elliott found that repeated excitation of the sciatic nerve was especially efficient in exhausting the adrenal glands of their adrenalin content, and also that this reflex persisted after removal of the cerebral hemispheres.? It was to be expected, therefore, that with well-stored glands, sciatic stimulation, even in the decerebrate animal, would call forth an amount of adrenal secretion which would decidedly hasten clotting. The following case illustrates such a result: 1 CANNON: This journal, 1914, xxxlll, p. 357. ? EvuiottT: Journal of physiology, 1912, xliv, pp. 406, 407.](https://iiif.wellcomecollection.org/image/b33443750_0003.jp2/full/800%2C/0/default.jpg)
