A clinical study on primary carcinomatous and sarcomatous neoplasms between the folds of the broad ligaments : with a report of cases / by J.E. Janvrin.

  • Janvrin, J. E. (Joseph Edward), 1839-1911.
Date:
1891
Catalogue details

Licence: Public Domain Mark

Credit: A clinical study on primary carcinomatous and sarcomatous neoplasms between the folds of the broad ligaments : with a report of cases / by J.E. Janvrin. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    sense of the word, called a sarcoma; neither did they give the impression of having been cut from a truly inflammatory, tuber- cular, or syphilitic type of tissue formation. On the other hand the sections presented appearances which would lead to the sup- position that some form of local irritation—but not of specific origin—had disturbed the equal and uniform distribution of the nutritive supply to the part and caused an irregular supply which had resulted in this unequal development of the various forms of connective-tissue substance formation, the result of which was, that no particular kind of tissue predominated with sufficient uniformity to give to the neoplasm any distinctive characteristic by which it could be specifically named in accord with our present nomenclature. “ Scattered throughout the section, at irregular intervals, there were found small extravasations of blood corpuscles, also small zones and streaks of blood pigment, which, together with the larger cavities containing the remnants of blood, suggested a primary injury as a causative agent in producing this peculiar neoplasm. “ That the parovarium was entirely involved was quite ap- parent from the dilated condition of its tubular structure and the enlargement of the contained epithelial cells, but the micro- scopic appearances were those of an adenoid hypertrophy of the organ and not of the cylindrical-celled epithelial carcinomatous class of growths. The extensive connective-tissue formations of the embryonic type pointed away from, rather than toward, a carcinomatous growth. These conditions, however, did not clearly explain the appar- ent malignancy of the disease; and the active and extensive changes of an epithelial character in the parovarium also sug- gested a more malignant nature. New sections were made from various parts of the neoplasm, and finally a few small zones were found in which the perivas- cular or lymphatic spaces were dilated and filled with epithelial cells. These epithelial corpuscles were packed into these elon- gated and irregular alveolar spaces without any definite order of airangernent and without any distinct intercellular substance. This positive type of pathological formation, together Avith
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