Sarcoma development occurring during the propagation of a haemorrhagic adeno-carcinoma of the mamma of the mouse / by B.R.G. Russell.

  • Russell, B.R.G.
Date:
1910
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Licence: In copyright

Credit: Sarcoma development occurring during the propagation of a haemorrhagic adeno-carcinoma of the mamma of the mouse / by B.R.G. Russell. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    15/46 (page 355)
    13a) was a mixed tumour, with the sarcomatous elements preponderating. The mixture of the two elements was very intimate, the sarcomatous tissue being closely applied to the epithelial tissue and forming a “ stroma” for the epithelial cells which were present, mostly in the form of narrow bands with irregular thickenings, radiating through the tumour. In the next generation this mixed tumour freed itself from the carcinomatous component, and has subsequently been propagated as a pure, spindle-celled sarcoma through seven generations (Plate XXI. Fig. 8). IJA- 12 lae- —^ ISO -15 ,st. isr- 30 J5L 48 • HC • • I4C ■ 25 • 15A a . iSK •I6A • • ISM - ■ nA • -IJH —• I5C — //jf H. CA/f^MOMA t3B • ISC 16 D 161. 160 146 - M/XCD Tl/MOa/f • C^es/ogicjf/ /tee o{ tumours c/esceuded from series o:/Ae ftumders ebove the tines £/ye /be ^£es in cinj^ of /he tumours. Three other tumours of I 2d which were transplanted Avere already pure spindle-celled sarcomata. A fifth tumour (I2d-13f) was a pure carcinoma, and a sixth (12d-I3q) Avas mixed. The explanation of the variations in histology of these daughter tumours lies in the method of inoculation and in the distribution of the sarcomatous tissue throughout the parent tumour. It was previously remarked that tumour 11a-12d Avas nearly all sarcoma at one end and pure carcinoma for the greater ]iiirt of the rest of the tumour. This distribution Avas ascertained from a frozen section previous to the transplantation of the tumour, according to the method devised by Haaland, and, as described above, the attempt Avas made Fig. I.—lOO/Hs, No. 12. Tumour, 46 days old, sliowing cystic degeneration of carcinoma, and segregation of carcinoma and sarcoma after inoculation of a mixed emulsion of these two tumours. ( x f.) by picking out small fragments (0’0I-0-02 gr.) to segregate the various com- ponents of the tumour. This explains the pure carcinomatous character re- tained by the tumour I2d-13f. Another form of segregation has been obtained by Apolant (1908°) Avhen attempting to produce mixed tumours artificially, by inoculating a mixture of pure carcinoma and pure sarcoma. He obtained in some cases genuine carcinoma-sarcomatodes, Avhilst other sister tumours Avere pure sarcomata or pure carcinomata. Fig. I shoAvs this segregation occurrin<^ in one animal for tumour “ 100.” ° Xone of the six daughter tumours in 13f attained to an age of 60 days, and all remained pure carcinoma. Only one of them Avas transplanted, giving