Sarcoma development occurring during the propagation of a haemorrhagic adeno-carcinoma of the mamma of the mouse / by B.R.G. Russell.

  • Russell, B.R.G.
Date:
1910
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Licence: In copyright

Credit: Sarcoma development occurring during the propagation of a haemorrhagic adeno-carcinoma of the mamma of the mouse / by B.R.G. Russell. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    4/46 page 344
    Journal of Pathology and Bacteriology, Vol. XIV. SARCOMA DEVELOPMENT OCCURRING DURING THE PROPAGATION OF A HAEMORRHAGIC ADENO- CARCINOMA OF THE MAMMA OF THE MOUSE/ By B. E. G. Russell, M.D. From the Laboratories of the Iniiurial Cancer Research Fund. Director, Dr. E. F. Bashford. (Plates XVIII.-XXL). The change occurring during the propagation of certain carcinomatous tumours whereby they become converted first into tumours consisting of sarcomatous and carcinomatous elements, which may in turn give place to tumours consisting of purely sarcomatous elements, ranks amongst the more interesting phenomena brought to light by the experimental investigation of cancer. The number of transplanted carcinomata in which this transformation has been observed has augmented considerably in the last four years (1905-8 1. 2. 19. 22. 23^_ The cases observed (1907) in the laboratory of the Imperial Cancer Research Fund have been fully described by Haaland (1908 who followed the sarcomatous change in nine different strains of tumour “ 37.” With the single exception of a tumour of the rat, all the cases of this transformation have been observed during the artificial propagation of mammary carcinomata of the mouse. It is not proposed here to go at length tino the literature on this subject, as it has been recently critically reviewed by Haaland in the introduction to his paper on “ Sarcoma Development.” Where necessary, the observations made upon the cases already recorded will be brought under review in the later development of this paper, and the results of the present observations will be used for the critical analysis, so far as possible, of the various theories already enunciated as probable explanations of this peculiar development. The question, whether the tumours produced are true sarcomata, has in our opinion been finally settled by Haaland’s (1906 1908^®! observations, and the single dissentient note given by Krompecher (1908 21) would not have been sounded had he waited for the full description of the tumour in question. The question of the origin of these sarcomatous changes in what were previously pure carcinomatous tumours is of extreme importance, bound up as it is so intimately with the general etiology of all neoplastic growths, and a careful analysis of all the cases observed is very desirable. The sarcomatous change has occurred in another of the propagable mouse carcinomata of the Imperial Cancer Research Fund, in a 1 Received November 10, 1909.
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