The coal-tar colors : with especial reference to their injurious qualities and the restriction of their use : a sanitary and medico-legal investigation / by Theodore Weyl ; with a preface by Professor Sell ; translated with permission of the author by Henry Leffman.
- Leffmann Henry, 1847-1930.
- Date:
- 1892
Licence: Public Domain Mark
Credit: The coal-tar colors : with especial reference to their injurious qualities and the restriction of their use : a sanitary and medico-legal investigation / by Theodore Weyl ; with a preface by Professor Sell ; translated with permission of the author by Henry Leffman. Source: Wellcome Collection.
Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.
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![Kidneys were deep yellow ; conjunctiva yellow. Contents of the bladder were orange-yellow and were turned red by concentrated sulphuric acid, and contained, therefore, the unchanged color. This animal received in the course of twelve days twenty-one grams of the color, or 0.53 gram per kilo of the body weight. This dose is fatal. Exp. J.—Dog weighing 5220 grams, on April 3d, had traces of albumin in the urine. April 6th, .1 gram in 10 c.c. of sterihzed water administered subcutaneously. Animal trembled a great deal. April 9th, .15 gram subcutaneously at two points. Animal trembled, but ate freely. April nth, .15 gram. No abscesses, animal Hveher, trembling no longer observed : urine contained traces of albumin. April 14th, weighed 4790 grams, was hvely and took food. Metanil yellow must be considered poisonous when admin- istered by the stomach, from the indication of Experiments i and 2. The lethal dose, which is determined by Experiment 2, is 0.53 gram per kilo of the body-weight. The isomeric diphenylamine orange is, on the other hand, non-poisonous. Azarin S. Azarin S is obtained by the diazotizing of amidodichlor- phenol, joining the compound with /3-naphthol, and treating the resulting color with ammonium acid sulphite. The operation, therefore, takes place in two steps : one, the production of the azo-color; secondly, addition of the ammonium acid sulphite. For the product of this reaction, the following formula is gener- ally assumed.* Clj C.HjHO NH — NCioHgHO NH^SOa The^color itself is'insoluble, but becomes soluble through the addition of the acid sulphite. If the azarin S so prepared is printed together with aluminum acetate on cotton goods, and * [The formula for azarin is given differently by different autborities.— Trans.]](https://iiif.wellcomecollection.org/image/b21700588_0134.jp2/full/800%2C/0/default.jpg)
