Idiosyncrasies / by Sir Humphry Rolleston.

  • Humphry Rolleston
Date:
1927
Catalogue details

Licence: In copyright

Credit: Idiosyncrasies / by Sir Humphry Rolleston. Source: Wellcome Collection.

    49/128 page 45
    (b) hypersensitiveness, the result of infection. (a) Anaphylaxis: in man hyper¬ sensitiveness produced by an intravenous injection of a foreign protein, such as horse serum which is the usual medium for antitoxins, to a subsequent injection of the same protein in however small a quantity is well recognized, but is not seen with the same regularity as in laboratory animals. Indeed the mani¬ festations of the anaphylactic reaction or shock produced by a second injection of the same protein are not the same in different species of animals ; in guinea- pigs there is spasmodic contraction of the small bronchial tubes, thus reproducing the condition in human asthma, and, as guinea-pigs are specially sensitive, death often results ; in rabbits the symp¬ toms are chiefly circulatory, and in dogs abdominal, namely great vascular en¬ gorgement of the intestines and of the liver which shows focal necroses. In man anaphylactic shock is rare, as is shown by its exceptional occurrence in the large number of men who received
    digitised image 1
    digitised image 2
    digitised image 3