Researches on morphine. Pt. 2 / by S.B. Schryver and Frederic H. Lees.

  • Samuel Barnett Schryver
Date:
[1901]
Catalogue details

Licence: In copyright

Credit: Researches on morphine. Pt. 2 / by S.B. Schryver and Frederic H. Lees. Source: Wellcome Collection.

    20/22 (page 580)
    The alkaline aqueous solution from which all the /3-isomorphine had been extracted by chloroform was then shaken out with successive amounts of hot amyl alcohol, until the aqueous portion, after acidify¬ ing, showed no reaction on the addition of Mayer s reagent. The amyl alcoholic solution, after washing once with a little water, was extracted several times with dilute hydrochloric acid, and the acid aqueous solution of the hydrochloride evaporated to a small bulk, alcohol added, and the evaporation continued. This addition of alcohol, followed by evaporation, was repeated several times, when the hydrochloride was obtained as a crystalline cake which, after mixing with more alcohol, was drained and washed at the pump. The salt was then dissolved in water, from which solvent it crystallised. Two fractions of crystal¬ line hydrochloride obtained from water, on determining their specific rotations in aqueous solution, gave the following results respectively : aD — -4°4'; 1=2 dcm. ; c = 2T7 ; [a]D = -94°. aD= -3°51'; ^ = 2 dcm.; c = 2-081; [a]D= -92-5°. It would thus seem as if this were a pure hydrochloride of a base which has not hitherto occurred during the course of this work. Its further investigation, together with that of /3-isomorphine,will, however, form the subject of a future communication. - The Wellcome Chemical Research Laboratories. RICHARD CLAY VXD SONS. LIMITED, LONDON AND BUNGAY