Researches on morphine. Pt. 2 / by S.B. Schryver and Frederic H. Lees.

  • Samuel Barnett Schryver
Date:
[1901]
Catalogue details

Licence: In copyright

Credit: Researches on morphine. Pt. 2 / by S.B. Schryver and Frederic H. Lees. Source: Wellcome Collection.

    3/22
    S. L. Sciiryver and FrePeric II. Lees. In our last communication (Trans., 1900, 77, 1024), we showed that wien morp me, C17H]903Iv, is treated with phosphorus tribromide, the alcoholic hydroxyl group is replaced by a bromine atom, and bromo- lphide, Ci;HI802NBr, is obtained. This substance, on treatment With water, decomposes according to the equation : Ci7HiS02NBr +1120 = C17H190,N,HBr. The base, isomeric with morphine, obtained from this hydrobromide was designated isomorphine. Further investigation, however, has re¬ vealed the fact that the product is a mixture of the hydrobromides of <ico isomeric bases, neither of which is identical with morphine The properties of isomorphine, as given in our last paper, are correctly de¬ scribed, since, by the methods of purification adopted, it was obtained quite free from the second isomeride, for which we now propose the name ^morphine. The latter substance is obtained in much small, r quantities than woraorphine ; its specific rotation is considerably higher and it is characterised by the fact that it crystallises with 4-mol of