The therapeutic value of the mixed toxins of the streptococcus of erysipelas and bacillus prodigiosus in the treatment of inoperable malignant tumors : with a report of one hundred and sixty cases / by William B. Coley.

  • Coley, William Bradley, 1862-1926.
Date:
1896
Catalogue details

Licence: Public Domain Mark

Credit: The therapeutic value of the mixed toxins of the streptococcus of erysipelas and bacillus prodigiosus in the treatment of inoperable malignant tumors : with a report of one hundred and sixty cases / by William B. Coley. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    22/34 page 20
    Case XIV.—Angiosarcoma of the breast. erysipelas and bacillus prodigiosus. This serum was prepared by Mr. Bux- ton in a manner similar to the diphtheria-serum—the toxins of erysipelas and prodigiosus having been injected daily into a horse for about six weeks, and the serum then withdrawn. Effect of the injections. In small doses of 5 to 10 minims very little effect was noticed. Larger doses, 15 to 20 minims, frequently caused intense mus- Fig. 14. Fn;. 15. Case XIV.—Angiosarcoma of the breast. cular pain and an urticaria-like condition of the skin, sometimes extending over the whole back and chest, being the cause of intense itching and dis- comfort. Patient also complained of very severe headaches, lasting sometimes for several days. The dose was never carried beyond 20 minims, but was, as a rule, given daily. The tumor soon began slowly to decrease in size, and January 20, 1895, and placed in the “incurable” ward. The disease was so far advanced and the general condition was so bad that no attempt was made to give her the toxins. After the ulcerated surface had become somewhat less foul under careful treatment, and her general condition a little improved, she was placed under treatment with injections of the antitoxin-serum of Fig. 12. Fig. 13.
    digitised image 1
    digitised image 2
    digitised image 3