An experimental research on the antagonism between the actions of physostigma and atropia / by Thomas R. Fraser.
- Fraser Thomas R. (Thomas Richard), Sir, 1841-1920.
- Date:
- 1872
Licence: Public Domain Mark
Credit: An experimental research on the antagonism between the actions of physostigma and atropia / by Thomas R. Fraser. Source: Wellcome Collection.
Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.
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![m H ;> I—I p H CO p < I—I I—I Ph O H m I—I O I—I H m O CO Ph H < O m H o o >—I H P^ pq H P^ P m P^ I—I P^ pq CO o CO 1 o CO O CO a P4 o o p w CO H Ed pp s? o g ■—■ CD o O _n ^ >^>—I crt m S a o ce -a eggs *M ^ ^ g ^ § ^§ g ■3:2 o 5 as o .2 g J. 1^ a?I '^^ '2 ■'^^ t:^ ^ f3 c« •S >^ CO ^ ^ a rp, ^3 S +^ .S >> r 'ci .s CD (1) CO p., 2-^ ■§ S ^ c/; +J N ■ ; s b 2 = ^ S d s ^ S ° a a ; 3 ca iQ a J a .a i-( a c5 cn 03 CD c3 a . a o a ^ •§.2 ci o ^ ^ -.ago 2 a^ § .a.2<^' § .a o ■4J a tjo a ■ a '^^ a a o S fi a - 8i a «'3 a ■5 fl .ba a- -3 '.2 CO »C - J 2 - e ^ +^ 10 - rt ^?2^ a S N a CO cj CO 9 g.^ ^5 ci I C^ G> ci a' . 'o <^ a p <N - S ^ {/J C3 t>s ■ .-^ ^-g > 5= -I a -i^ ..2 fiO'^ , -& CM cci IP > I-r r a o 2 •'•2>'^ se 00 a s a CO be CO a .S S ci ^ 1 a > 'I^ a i.2 « 5 > ci a (c 3 CO ci CO a a '-'.p CO oi a f= 'a S ^ - ^-o2cD f^Sag<Dmr-j J- CD +^ ^ —. ■5^ CO ^ CO H CO r ^ • a ts • feacg^la I >—' I—I CO d fi 3 fi S (D ci ijS bp m ' CD 10 a ci _, a '''.2 a •- CD fi ^ CO „ +3 ci o „ •§ 6 a c:y CD •- S~ CO rH 10 t^- ' : S '^ S H Cl,^ !i| g (TO 10 ,:a Effect on the Heart. With physostigma, in 4 min., slowing from 39 to 38 x^er 10 sec. After atropia, the rate per 10 sec. was in 2 min., 58 ; in 4 min., 60 ; in 16 min., 62; and in 1 hour, 51.—On the following day, it was 50 ; and on the 3rd day, 40. With physostigma, in 4 min. 30 sec, slowing from 40 to 32 per 10 sec. After atropia, the rate per 10 sec. was in 4 min., 53 ; in 30 min., 38 ; in 1 hour 18 min., 28 ; in 1 hour 40 min., 32 ; and in 2 hours 13 min., 36.—On the fol- lowing day, it was 33 ; and on the 3rd day, 60. With 2}hysostigma, in 4 min. 30 sec, slowing from 43 to 32 per 10 sec. After atropia, the rate per 10 sec. was in 2 ]nin., 58 ; in 4 min., 63 ; in 7 min., 67 ; in 30 min., 50 ; in 1 hour, 43 ; in 1 hour 25 min., 38 ; and in 2 hours 35 min., 32.—On the fol- lowing day, it was 42 ; and on the 7th day, 40. Effect on tlie Pupils. (The Measurements are in fiftieths of an inch.) ii 1**1 i? iiiidkt B -isisil •t^ 8 a a i -li -S^'S a .2 ^ d S g '.^^ e a' S ^ .t^ J I^Ssg^a.g-co .^2*g•.2*t |^ S . ^2.2 * 1^1 * feH*^ISI.te fegx^gs*^*.! ^hWIS*!** Result. Recovery. Recovery. Recovery. 1 i - Doses of Sul- 1 phate of Atropia (in Grains). Dose p. 3 lbs.of Animal. t-, 1>- Actual Dose. 01 J>- i— CO a. 5J 03' 03 o P.S S OJ (U c C CJ 5W -](https://iiif.wellcomecollection.org/image/b21730490_0128.jp2/full/800%2C/0/default.jpg)