Some pathological and other conditions observed among the human remains from a prehistoric Ethiopian cemetery in the Southern Sudan / [M.B. Ray and L.H.D. Buxton].

  • Ray, Matthew B. (Matthew Burrow), 1870-
Date:
1914
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Licence: In copyright

Credit: Some pathological and other conditions observed among the human remains from a prehistoric Ethiopian cemetery in the Southern Sudan / [M.B. Ray and L.H.D. Buxton]. Source: Wellcome Collection.

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    paroxysmal hemoglobinuria and Raynaud’s disease are tlie same thing, i.e., that hsemoglobinuria is a symptom of the more general affection. He suggests even that the jaundice some¬ times found after attacks of hemoglobinuria (and also after attacks of local asphyxia) is the result of arterial spasm of the hepatic vessels. The view which would now probably find more acceptance, is that the discoloration is a hematogenous jaundice, due to the breaking up of hemoglobin in the blood stream elsewhere. Several observers have pointed out that during a paroxysm of intermittent hemoglobinuria, blood drawn from a cold extremity shows marked changes in respect to the corpuscles. They do not form rouleaux, and are markedly crenated, and granular masses appear in the surrounding serum. Murri,* of Bologna, believes that there is corpuscular destruction in the superficial vessels in which stagnation has occurred, and that arterial spasm, whatever its cause, is an essential factor in the disease. He holds that the corpuscles are broken up by the combined action of cold and carbonic acid.f Boas J found that corpuscular changes could be brought about in the blood drawn from the finger of a patient who was the subject of paroxysmal hsemoglobinuria, by plunging the finger for a time into a dish of iced water ; and Fleischer § found that in one of his hsemoglobinuria patients a blister, which had been applied to the skin during an inter-paroxysmal period, gave evidence of the presence of haemoglobin in its serum, after a paroxysm of hsemoglobinuria had occurred. In the above observations no special regard has been made to the occurrence of local asphyxia of the extremities, but Hr. Mversil has recorded a case which completes the group in the sense that there are blood changes, local asphyxia of extremities, and intermittent hsemoglobinuria occurring in the same patient. A boy, aged 12 years, who was under the care of Hr. Cavafy for paroxysmal hsemoglobinuria, dated his first attack five years back when recovering from measles. About the same time, or * Dell Emoglobinuria dafreddo. Bologna, 1880. f Quoted from Dickinson. Vide also lecture by Dr. Stephen Mackenzie, Lancet, 1881, i., p. 156. J Deutsches Archie far Klinische Median, 1883, p. 355. § Berl, Klin. Wochenschrift, 1881. No. 47, p. 694. j] Trans. Clin. Soc., xviii., p. 336,
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