Vaccine therapy, its theory and practice / By R. W. Allen.

  • Allen, R. W., 1876-1921.
Date:
1910
Catalogue details

Licence: Public Domain Mark

Credit: Vaccine therapy, its theory and practice / By R. W. Allen. Source: Wellcome Collection.

Provider: This material has been provided by the Harvey Cushing/John Hay Whitney Medical Library at Yale University, through the Medical Heritage Library. The original may be consulted at the Harvey Cushing/John Hay Whitney Medical Library at Yale University.

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    ANTICHOLERA VACCINATION incubation being, however, carried on at 35° C. instead of at 39° C, as the former is the optimum temperature for the Vibrio cholera. The dose of this strong vaccine is also 1 c.c. One or two injections of the weaker vaccine are made subcutaneously into the flank at intervals of three to five days, a dose of the stronger being given five days after the last of the weaker. The injections cause moderate pyrexia, general malaise, and headache, while locally tenderness and swelling of the corresponding lymph glands result. These symptoms all pass off in about three days. Kolle1 advises the use only of a vaccine of the fully virulent organisms, and finds that the local necrotic effects which were anticipated do not occur. He claims that more rapid immunity results. The full immunity from each inoculation is attained in about five days, so that it is complete in about ten days, and is said to last for at least a year. The good results are seen in a reduction of the incidence of the disease, and not of the case mortality, which appears to be uninfluenced. This may be seen in the table given below, which is compounded of the recorded results from numerous sources spread over several years : TABLE XXII. Uninoculated.. Inoculated Population. Cases. 18,355 12,744 667=3-6% 84 = 0-66 /o Deaths. i Fatality. 393=2-1% 48=0-4% 59% 57% 1 Centralb. fur Bad., 1896, Bd. xix.