The determination of blood groups / [Medical Research Council Blood Transfusion Research Committee].

Date:
1943
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Licence: Public Domain Mark

Credit: The determination of blood groups / [Medical Research Council Blood Transfusion Research Committee]. Source: Wellcome Collection.

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    transfusion is desirable when group O blood is to be given, and is essential when blood of any other group is to be given. When workers with sufficient laboratory experience to make this test are not available, group O blood may be used without direct matching. A pilot tube containing blood collected at the time of blood donation should not be used for matching. (7) The essential properties of test sera are defined as follows: (i) high titre: (ii) capacity to react with A, and A,B cells: (iii) the absence of cold agglu- tinins: (iv) the absence of rouleaux-forming properties: (v) the absence of excess fat: (vi) the absence of contamination. (8) The possible sources of error in blood group determinations include: (i) failure to use sera showing the above properties: (ii) failure to store at- low tempera- ture: (ili) pseudo-agglutination or rouleaux formation: (iv) cold agglutination : (v) the Thomsen phenomenon with infected cell suspensions. (9) The significance of the Rh factor is discussed, and methods of detecting Rh agglutinogens and anti-Rh agglutinins are described. (10) The necessity of entrusting group determinations only to trained personnel is emphasised. REFERENCES A bibliography covering the recent work on blood grouping would be unduly extensive for a memorandum of this nature. References to the literature concerned with the ABO blood groups may be found in WIENER, A. S. (1939) Blood Groups and Blood Transfusions, 2nd edit. London. Publications relating to the Rh factor are listed in Boorman, K. E., Dopp, B. E., and Motiison, P. L. (1942) Brit. med. J., Hi, 535 and 560. B2722. Wt.2507. 15,000. 5/43. U.B.L. G.428.
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