Glioma retinae : with report of five cases / by Christian R. Holmes.

  • Christian Rasmus Holmes
Date:
[1902]
Catalogue details

Licence: In copyright

Credit: Glioma retinae : with report of five cases / by Christian R. Holmes. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    (a) Origin in layer of optic nerve fibers 5 castis Origin in inner nuclear layer 19 case.=i Origin in any of the innei- layers of retina 12 cases Total 36 cases (b) Origin in outer nuclear layer 9 cases Origin in outer layers of retina 3 cases Total 12 cases From this we will observe that the origin is three times more frequent in the inner than in tlie outer layers. We must remember that the origin is not limited to one layer of the retina, but may spring from several layers in the same case. It has been observed that gliomata have their origin four times more frequently from the posterior than from the anterior half of the globe. The same author accepts Cohnheim's theory that tumors have their origin in the masses of embryonic cells which are at times left over in the building of the normal structure^ these cells remaining dormant in their embryonic state until at some later period they may take on an active and perverted growth. Prof. Schobl, who has observed a very large number of this class of tumors, concludes that glioma may start from the supporting fibers of any of the layers of the retina, but mostly from the inner nuclear layer. In this layer Da Gama Pinto found that the nuclei were mostly in process of division with karyokinetic figures. That glioma is a form of tumor independent of and different from sarcoma, was first doubted by Cornil and Eanvier: later thev were termed small round-celled sarcomata by Delafield, and Nagel agreed in this opinion. From Virchow's stand- point the supporting tissue of the retina can not be considered identical with common connective tissue, and from the standpoint of Klebs the gliomata arc derived even fi'om a different germinal layer than llint from whicli tile sarcomata arise. The clinical picture of <ilioma also is so well defined that to confound it with sarcoma is against good judgment. Becker thinks that there is a sufficient numl)er of mesoderm c(>lls in tlie blood c(»lls to giv(^ rise to sar- comata. To this il miisl be aus\v(M-cMl that theii oi'igin