The Croonian lectures on some points in the pathology of rheumatism, gout and diabetes : delivered at the Royal College of Physicians, London, March 30, April 1, 6, 1886 / by P.W. Latham.

Latham, Peter Wallwork.

Date:: 1887

Credit: The Croonian lectures on some points in the pathology of rheumatism, gout and diabetes : delivered at the Royal College of Physicians, London, March 30, April 1, 6, 1886 / by P.W. Latham. Source: Wellcome Collection.

Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.

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$IL] 59^ But ifc is important to know what are tlie intermediate stages, if we are to understand the mode of formation of this substance in the living body. 'Now hydantoic acid has been formed synthetically, and here we have the first step towards the synthesis of uric acid. By heating urea and glycocine to a temperature of 120—125° C. they combine and form hydantoic acid * CO-^ +CHJ =NH3 + C0^ (NH2 (COOH (NH - CH2 - COOH urea glycocine hydantoic acid and this dehydrated forms hydantoin; for by boiling the latter with baryta water it is converted into hydantoic acid , (NH-CO (NH2 C04 I +H,0 = CO-^ (nH - CH2 (NH - CH2 - COOH hydantoin hydantoic acid By heating urea alone to a temperature somewhat higher, viz. to ISO'*—160 C, condensation takes place, and it is converted into biuret C2O2N3H5. [NH, . (NH, CO 2C0 \ = NH3 + ;nh (nh^ CO INH, urea biuret If now we combine together hydantoin and biuret we have the elements of water and ammonium urate, (NH-CO COJ CO ] i + NH = H2O + C5H3N4O3. NH, (NH - CH2 CO J ammonium urate INH2 hydantoin biuret * Ueintz, Jahresb. fur Chem. 1865, S.S60.$