The present aspect of the doctrine of cellular pathology : a lecture delivered at an evening meeting of the Royal College of Surgeons of Edinburgh, 27th February, 1863 / by Sir William Turner.
- William Turner
- Date:
- 1863
Licence: Public Domain Mark
Credit: The present aspect of the doctrine of cellular pathology : a lecture delivered at an evening meeting of the Royal College of Surgeons of Edinburgh, 27th February, 1863 / by Sir William Turner. Source: Wellcome Collection.
Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.
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![of the membrane was covered. These were, without doubt, derived by division from the original nucleus of the connective-tissue cells. This process of endogenous multiplication was seen to the greatest advantage in those parts of the connective tissue in which the pro- liferation was in its early stage, for here individual as well as small groups of corpuscles could be separately examined; but in those portions of the membrane in which the production of new cells had been for some time going on, the new structures were so numerous as entirely to obscure the original elements of the texture. Changes of an exactly corresponding nature have been traced by Cohnheim (op. cit.), and with much more detailed minuteness, in inflammations both of the pericardial and peritoneal membranes. 8$, In the Skin.—In the skin, as in the mucous and serous mem- branes, both epithelial cells and a sub-epithelial connective tissue are met with: the former constituting the cuticle or epidermis, the latter the cutis or true skin. Both the cuticle and cutis participate in the process of suppuration.1 The corpuscles of the connective tissue, of which the cuti3 is composed, go through all those pro- ductive changes of nuclear division and mother-cell formation which I have already described as occurring in the formation of pus in the connective tissue in other parts. The cuticle or epidermis possesses considerable relative thickness, and consists of many layers of cells, which may be regarded as arranged in two strata—a superficial or horny stratum, and a deeper, softer stratum, known to the older anatomists as the rete Malpighii. The more superficial of these two strata does not appear to take any part in the suppurative process, but either becomes elevated, as in the formation of blisters, or else separates in fine scales, as in the course of pointing of an ordinary abscess. The cells of the rete Malpighii are those in which the pus is produced. They pass through all those changes of constriction and division of the nucleus which result in the formation of groups of nuclei in a single eel], and various forms of division of the cell may not unfrequently be seen. From these, as from the instances already cited, pus corpuscles are produced in a quantity propor- tioned to the intensity of the process and the extent of the area affected. At the same time, as so frequently happens, not only in inflammation of the skin but of other textures, many of the cells undergo destruction by fatty degeneration. 9th, In Secreting Glands.—If we were now to direct our attention to the secreting glands, and inquire into the changes which take place in them in the course of the inflammatory process, we should find that both the secreting epithelium-cells and the connective-tissue matrix take part in the process. In illustration, perhaps, it may suffice if we limit ourselves to an examination of one of these glands, and we will take, as an example of the rest, the kidney. It has long been known that the secreting epithelium of the kidney-tubes is materially affected in inflammation of the gland, and the various](https://iiif.wellcomecollection.org/image/b21455521_0021.jp2/full/800%2C/0/default.jpg)
