Studies upon leprosy. V. A report upon the treatment of six cases of leprosy with nasteine (Deycke) / by Walter R. Brinckerhoff and James T. Wayson. VI. Leprosy in the United States of America in 1909 / by Walter R. Brinckerhoff.
- Brinckerhoff, Walter Remson, 1874-1911.
- Date:
- 1909
Licence: In copyright
Credit: Studies upon leprosy. V. A report upon the treatment of six cases of leprosy with nasteine (Deycke) / by Walter R. Brinckerhoff and James T. Wayson. VI. Leprosy in the United States of America in 1909 / by Walter R. Brinckerhoff. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![Duration of treatment.—The cases were under nastine medication for from four months, three weeks, and live days to one year and three months (case ], one year and three months ; case 2, nine months and three weeks; case 3, one year, two months, and two weeks; case 4, eight months and two weeks; case 5, one year, one month, three weeks, and three days; case 6, four months, three weeks, and live days). Dosage.—Our experience with dosage can be summed up as fol- lows: Prolonged administration of small doses seemed to have no effect upon the progress of the disease, while an increase in the dose caused muscular pains, which necessitated a reduction of the dose or an abandonment of the treatment before any amelioration of the symptoms of the disease was observed. In three cases we made comparisons of the condition of the bacilli in the lesions before and after nastine medication and found no change in the distribution of the acid-fast substance. CONCLUSION. 1. In our hands the administration of nastine to six cases of lep- rosy gave slightly encouraging results in two cases. In one of these the lesions decreased in extent and took on a focal character. In the other case a tubercle disappeared during the treatment. 2. Four cases seemed unaffected by the treatment, even when persisted in for over a year. 3. Constitutional reactions were only seen when the dosage was large. No local reaction or puriform softening of tubercles was observed.® We wish to express our indebtedness to Dr. J. T. McDonald, terri- torial bacteriologist, for excerpts from his records. “ At one time we were inclined to attribute the failure of constitutional and other reactions to an inactivation of the preparation resultant upon adverse conditions in transit to us from the makers, but a box of six doses of nastine B. 1 returned by us to Kalle & Co. was reported by them to be active.](https://iiif.wellcomecollection.org/image/b22426796_0015.jp2/full/800%2C/0/default.jpg)
