Notebook 3

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Dr. Wyatt's first notebook to be titled Nucleic Acids, written during his time at the Molteno Institue, Cambridge, England. The book contains details of nucleic acid preparations from Locusta migratoria, herring sperm, the bacteria E. coli, beef spleen, calf thymus, the bacteriophage T2, the moth Dedrolimus pini, Ld virus, and both human and bovine tubercle bacilli. This notebook also contains Dr. Wyatt's first mention of an "extra spot" which appeared in his chromatograms, which separated bases from hydrolysed nucleic acids purified from herring sperm. The notebook later contains details of Wyatt's attempts to prepare a sample of the 'extra spot' for later identification as 5-methylcytosine. At the back of the book are written methods for several procedures including the "extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid"

Notebook 3

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