Secondary degeneration following unilateral lesions of the cerebral motor cortex / by Sutherland Simpson.
- Sutherland Simpson
- Date:
- 1902
Licence: In copyright
Credit: Secondary degeneration following unilateral lesions of the cerebral motor cortex / by Sutherland Simpson. Source: Wellcome Collection.
Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.
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![into the formatio reticularis of tlie opposite side and still fewer into that of the same side. In the lower levels of the decussation a few small bundles of degenerated fibres (homolateral) passed to the cros- sed pyramidal tract of the same (left) side, and in the spinal cord a few fibres forming a direct lateral pyramidal tract were seen Avhich were traced as far as the sacral segment. No direct anteiior pyramidal tract was found in any of the animals examined. With regard to the connection between the grey matter of the optic thalamus and the pyramidal tract Monakow [11] as early as 1884, employing the method of von Grudden removed the motor area on one side in rabbits and cats, and as a result found, amongst other things, atrophy of the grey matter of the optic thalamus of the same side. Amongst recent observers Boyce [13] in the cat, in 1894 and Melius [14] in the monkey, in the same year, both using tlie method of Marchi, were able to trace fibres from the pyramidal tract into the optic thalamus of the same side. Many investigators have found either atrophy of, or iine (termi- nal) degeneration in the substantia nigra in relation to the degenerated crusta according to the method employed. Monakow [11] iu 1884 in rabbits and cats, Sherrington in 1890 in monkeys, Langley and Griinbaum [16] in the same year in a dog. Melius [14] in 1894 in monkeys, and Dejerine and Long [17] in 1898 in the human subject, have recorded their observations on this point. Fibi-es passing from the crusta to the anterior corpora quadri- gemina have been previously observed by only two workers so far as I know, viz: — Muratoff [18] in 1893 and Boyce [13] in the follow- ing year. Boyce describes them in two cats as isolated fibres coming off from the outer extremity of the degenerated crusta and curving round to the quadrigeniinal region. Muratoff figures them as passing towards the lateral border of the. central grey matter. I have not found these fibres in the dog or in either of the two monkeys Avhich I have examined, but they were present in 14 out of the 16 cats ex- perimented upon, and in several cases they were very numerous. They do not come off from the outer extremity alone, as stated by Boyce and Muratoff, but from the whole posterior aspect of the de-](https://iiif.wellcomecollection.org/image/b21455727_0024.jp2/full/800%2C/0/default.jpg)
