Determination of radicles in carbon compounds / by Dr. H. Meyer. Authorized translation by J. Bishop Tingle.

  • Meyer, Hans (Hans Johannes Leopold), 1871-
Date:
1903
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Licence: In copyright

Credit: Determination of radicles in carbon compounds / by Dr. H. Meyer. Authorized translation by J. Bishop Tingle. Source: Wellcome Collection.

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    pared and most conveniently purified by distillation under a pressure of 0.3 mm and subsequent crystalliza- tion from benzene. The amino acid is dissolved in N sodium Hydroxide solution (1 mol.) and mixed with the Chloride (2 mol.) in ethereal solution; the mix.ture is shaken by a machine at the ordinary temperature, and at intervals of 1-1.5 hours three times the above quan- tity of N alkali is added. At the conclusion of the experiment the aqueous liquid is separated, filtered, treated, if needful, with animal charcoal.and the naph- thalenesulphonic derivative precipitated by hydrochloric acid in excess.2 (5) ALKYLATION. Amino groups in certain leuco-bases and coloring matters are easily methylated 3 by heating a solution of the substance with zinc-dust, hydrochloric acid, and formaldehyde at 75°-8o°; the decolorised liquid is sub- sequently oxidised.either by exposure to air, or by lead peroxide and acetic acid. The remarks on dimethylsulphate (p. 32) apply also to the alkylation of amino- or imino-compounds. It is usually employed in ethereal solution without alkali.4 DETERMINATION OF THE NITRILE GROUP (C:N.) The nitrile radicle is determined by hydrolysis, the resulting ammonia or acid being collected. 0) Prolonged boiling with hydrochloric acid is usually sufficient to cause hydrolysis; the product is i~JTpr- 47 [2], 94. 2 E. Fischer, B. 35 (1902), 3779- s M. Prud'homme. Bull. 23 (1900). >*>• 69- * F. Ullmann and P. Wenner, B. 33 (i9°°)i 2476-