Determination of radicles in carbon compounds / by Dr. H. Meyer. Authorized translation by J. Bishop Tingle.

  • Meyer, Hans (Hans Johannes Leopold), 1871-
Date:
1903
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Licence: In copyright

Credit: Determination of radicles in carbon compounds / by Dr. H. Meyer. Authorized translation by J. Bishop Tingle. Source: Wellcome Collection.

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    (/) Acetic anhydride in aqueous solution has also becn successfully employed (cf. p. 7). (D) Acetylation by Means of Glacial Acetic Acid. Acetylation, especially that of alcoholic hydroxyl groups, may often be accomplished by heating the -substance with glacial acetic acid, under pressure if necessary; the addition of sodium acetateis also ad- vantageous, and, in some cases, this is the only method wh.ch gives the desired result. Thus, camphorpinacone yields a chlonde when treated with acetyl Chloride, and is not changed by boiling acetic anhydride, but when it is boiled with glacial acetic acid for a short tune, a stable acetyl derivative is formed, and an isomenc “labile ” one by the action of the acid at the ordinary temperature during twenty-four hours.1 2 (E) Acetylation by Means of Chloracetyl Chloride. This reagent has also been employed occasionally.* A collection has been made of references in the lit- erature to hydroxyl derivatives which are not capable of acetylation.3 ISOLATION OF THE ACETYL DERIVATIVES. Acetyl derivatives are isolated by pouring the pro- duct of the reaction into water. The excess of acetic acid may also be removed by the addition of methylic alcohol to convert it into methylic acetate, which is 1 Beckmann, Ann. 292, 17. 2 Klobukowsky, B. 10. S81. Cf. Und. 31, 2790; 20, 2330. 3 M. 19, 22.